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- 文献和实验
- 技术资料
- 英文名：
Recombinant Human p53 Mutant
- 供应商：
艾美捷科技有限公司
- 规格：
2μg&5μg&10μg
【产品形式】：艾美捷为您提供的【p53 Mutant】重组人p53突变体蛋白产品是Sterile Filtered clear solution. p53 Mutant at 100ug/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
【背景资料】：p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
以色列ProSpec-Tany公司专注于细菌来源重组蛋白质生产。其独有细菌和哺乳动物表达和蛋白折叠技术使其成为国际一流科研级蛋白供应商。ProSpec-Tany是世界上能提供蛋白种类最多公司之一。领先生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。作为多家知名品牌代理，艾美捷与ProSpec一起为研究者们提供最好、最新细胞生物学研究工具而不断扩大产品及服务质量。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看中国生命科学试剂产品评论网站。
点击【p53 Mutant】重组人p53突变体查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-1454垂询Prospec中国区域授权总代理艾美捷科技有限公司。
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文献和实验Generation and Characterization of p53 Mutant Mice
p53 is one of the most well-characterized members of the tumor suppressor gene family. The role of p53 in controlling cellular homeostasis has proven critical, with over half of all human tumors having either lost or mutated p53
Lung-Specific Expression of Mutant p53 as Mouse Model for Lung Cancer
where adenocarcinomas often arise. In human lung cancer, both the frequency and type of mutations in the p53 gene can act as fingerprints providing information about external etiological agents, carcinogen exposure, and host factors affecting the carcinogenesis process (6) .
Detection of K-ras and p53 Mutations by Mutant-Enriched PCR-RFLP
, since they fulfill many criteria that link their de novo appearance to the process of field cancerization (4 ). Oncogene mutations of the ras - and p53 -type are found in chronic smokers and patients with preneoplastic and neoplastic lesions
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