Tri-泛素蛋白 (Ub3,线性的) | Tri-ubiqu

【产品形式】：艾美捷为您提供的Tri-泛素蛋白 (Ub3,线性的)形式为Lyophilised. Soluble and stable in aqueous solutions

【背景资料】：The post-translational modification of proteins with polyubiquitin chains occurs in a wide range of signalling pathways and is tightly regulated in order to ensure cellular homeostasis. The function, processing and ultimate fate of polyubiquitinylated proteins is thought to be determined by the nature of the linkage between adjacent ubiquitin molecules in the polyubiquitin chain. In addition to lysine-linked polyubiquitin chains the amino terminus of ubiquitin can be used to form head-to-tail polyubiquitin chains, in which the C-terminal Gly of one ubiquitin is conjugated to the N-terminal Met of an adjacent ubiquitin. Such linear polyubiquitin chains are structurally similar to Lys63-linked polyubiquitin, despite the chemical differences between the two linkage types. Several ubiquitin polygenes are encoded in eukaryotic cells and undergo post-translational processing to generate the cellular source of free ubiquitin monomers. However, linear polyubiquitin chains have been shown to be assembled in vitro by an E3 ligase complex, known as the linear ubiquitin chain assembly complex (LUBAC), and ubiquitin binding domains (UBDs) with a preference for linear polyubiquitin have been identified in a number of proteins. A possible role for linear polyubiquitin modification in NF-κB pathway activation, involving linear polyubiquitinylation of NEMO, has also been reported. Such observations suggest that linear polyubiquitin modification of proteins may play an important role in cellular processes in addition to that of lysine-linked polyubiquitin protein conjugation.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

点击Tri-泛素蛋白 (Ub3,线性的)查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询Viva Bioscience中国区域授权总代理艾美捷科技有限公司。