S5a 蛋白(人) (琼脂糖偶联物) | S5a prote

【产品形式】：艾美捷为您提供的S5a 蛋白(人) (琼脂糖偶联物)形式为Supplied as a 50% slurry containing 0.5mL settled resin in 50mM Tris-Cl, pH7.5, 150mM NaCl, 50% (w/v) glycerol, 1mM DTT, 0.01% sodium azide

【背景资料】：S5a, also known as PSMD4, is a major ubiquitin binding protein that binds preferentially to polyubiquitin chains. It is found as a non-ATPase subunit of the 19S regulatory complex of the 26S proteasome where it functions as a receptor for proteins destined for proteolytic degradation. In yeast, the homologue of S5a, Rpn10, is required for degradation of a subset of cellular proteins by the proteasome. Unlike other proteasome subunits, S5a exists predominantly as a free protein in the cytosol (i.e. not incorporated into the proteasome), though its precise role in the cytosol has yet to be fully elucidated. S5a contains two approximately 15 amino acid ubiquitin interacting motifs (UIM) which are responsible for its binding to polyubiquitin chains. In vitro S5a binds predominantly to chains of at least four ubiquitins in length and can act as a substrate for a wide range of ubiquitin E3 ligases, which, it has been suggested, occurs by a novel mechanism involving the association of S5a with growing poly-Ub chains. S5a conjugated to agarose at 0.5mg/mL. Has utility in the capture and detection of ubiquitin modified proteins and polyubiquitin chains.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

点击S5a 蛋白(人) (琼脂糖偶联物)查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询Viva Bioscience中国区域授权总代理艾美捷科技有限公司。