GsAF-II

GsAF-II
Blocker of Na_v1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7

GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Na_v1.1, Na_v1.2, Na_v1.3, Na_v1.4, Na_v1.6 and Na_v1.7 with IC₅₀ values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC₅₀ value of 4.7 µM.

GsAF-II technical information

AA sequence: Tyr-Cys²-Gln-Lys-Trp-Met-Trp-Thr-Cys⁹-Asp-Glu-Glu-Arg-Lys-Cys¹⁵-Cys¹⁶-Glu-Gly-Leu-Val-Cys²¹-Arg-Leu-Trp-Cys²⁵-Lys-Lys-Lys-Ile-Glu-Trp-OH
Disulfide bonds: Cys²-Cys¹⁶, Cys⁹-Cys²¹, and Cys¹⁵-Cys²⁵)
Length (aa): 31
Formula: C₁₇₆H₂₆₁N₄₇O₄₅S₇
Molecular Weight: 3979.78 Da
Appearance: White lyophilized solid
Solubility: aqueous buffer
CAS number: not available
Source: Synthetic
Purity rate: > 98%

12GSF002-00100	GsAF-II	0.1mg
12GSF002-00500	GsAF-II	0.5mg
12GSF002-01000	GsAF-II	1mg