Jingzhaotoxin III

Jingzhaotoxin III
Selective blocker of Na_v1.5 channel

Jingzhaotoxin-III (ß-TRTX-Cj1α) has been isolated initially from the Chinese Tarantula spider Chilobrachys Jingzhaovenom. Jingzhaotoxin-III selectively inhibits the activation of the voltage-dependent sodium channel Na_v1.5 with an IC₅₀value close to 350 nM. It is inactive on Na_v1.2, Na_v1.4, Na_v1.6 and Na_v1.7 and should therefore be considered as an interesting research tool to discriminate between sodium channel subtypes. Jingzhaotoxin-III binds onto receptor site 4 presumably located on DIIS3-S4 linker of Na_v1.5 and supposedly blocks Na_v1.5 through a different mechanism thanProTx-II and Huwentoxin IV. ß-TRTX-Cj1α is composed of 36 amino acid residues including 6 cysteines cross-linked according to a C1-C4, C2-C5 and C3-C6 pattern. Jingzhaotoxin-III also inhibits K_v2.1 channel with an IC₅₀ of around 700 nM.

Jingzhaotoxin-III technical information

AA sequence: Asp-Gly-Glu-Cys⁴-Gly-Gly-Phe-Trp-Trp-Lys-Cys¹¹-Gly-Arg-Gly-Lys-Pro-Pro-Cys¹⁸-Cys¹⁹-Lys-Gly-Tyr-Ala-Cys²⁴-Ser-Lys-Thr-Trp-Gly-Trp-Cys³¹-Ala-Val-Glu-Ala-Pro-OH
Disulfide bonds: Cys⁴-Cys¹⁹, Cys¹¹-Cys²⁴, and Cys¹⁸-Cys³¹
Length (aa): 36
Formula: C₁₇₄H₂₄₁N₄₇O₄₆S₆
Molecular Weight: 3919.53 Da
Appearance: White lyophilized solid
Solubility: aqueous buffer
CAS number: not available
Source: Synthetic
Purity rate:> 98%

12JZH003-00100	JZTx-III	0.1mg
12JZH003-00500	JZTx-III	0.5mg
12JZH003-01000	JZTx-III	1mg