Hainantoxin-IV

Hainantoxin-IV
Selective blocker of TTX-S VGSC

Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spiderOrnithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with an IC₅₀value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.

Hainantoxin-IV technical information

AA sequence: Glu-Cys²-Leu-Gly-Phe-Gly-Lys-Gly-Cys⁹-Asn-Pro-Ser-Asn-Asp-Gln-Cys¹⁶-Cys¹⁷-Lys-Ser-Ser-Asn-Leu-Val-Cys²⁴-Ser-Arg-Lys-His-Arg-Trp-Cys³¹-Lys-Tyr-Glu-Ile-NH2
(Disulfide bonds between Cys²-Cys¹⁷, Cys⁹-Cys²⁴, and Cys¹⁶-Cys³¹)
Length (aa): 35
Formula: C₁₆₆H₂₅₇N₅₃O₅₀S₆
Molecular Weight: 3987.6 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: Not available
Source: Synthetic
Purity rate: > 97%

12HTX001-00100	Hainantoxin IV	0.1mg
12HTX001-00500	Hainantoxin IV	0.5mg
12HTX001-01000	Hainantoxin IV	1mg