μ Conotoxin PIIIA

μ Conotoxin PIIIA
Blocker of Na_v1.4 channels

μ-Conotoxin PIIIA (mu-conotoxin PIIIA) has been isolated from the venom of the cone Conus purpurascens. μ-conotoxin PIIIA demonstrates a higher affinity for the mammalian muscle sodium channel Nav1.4 (IC50 ~ 44 nM) than for the CNS Nav1.2 subtype (IC50 ~ 640 nm). μ-Conotoxin PIIIA blocks more irreversibly amphibian muscle sodium channels than mammalian ones.

μ-Conotoxin PIIIA technical information

AA sequence: H-pGlu-Arg-Leu-Cys⁴-Cys⁵-Gly-Phe-Hyp-Lys-Ser-Cys¹¹-Arg-Ser-Arg-Gln-Cys¹⁶-Lys-Hyp-His-Arg-Cys²¹-Cys²²-NH₂
(Disulfide bonds between Cys⁴-Cys¹⁶, Cys⁵-Cys²¹ and Cys¹¹-Cys²²)
Length (aa): 22
Formula: C₁₀₃H₁₆₅N₄₀O₂₈S₆
Molecular Weight: 2604.10 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 97 %

08CON006-00100	μ-Conotoxin PIIIA	0.1mg
08CON006-00500	μ-Conotoxin PIIIA	0.5mg