Tocris货号3928-10mg与50mg现货XCT 79
0上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商- ￥3136.01
- Tocris bioscience
- 3928
- made in USA
- 2025年11月16日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 库存：
30⁺瓶
- 英文名：
XCT 790
- CAS号：
725247-18-7
- 保质期：
1年
- 供应商：
上海睿安生物19121878899
- 保存条件：
2-8°C
- 规格：
10mg/瓶
Tocris货号3928-10mg现货XCT 790上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Tocris货号3928-50mg现货XCT 790上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Chemical Name:3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide
Purity:≥98%
Biological Activity
XCT 790 is a selective ERRα inverse agonist(IC50 = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10μM. Interferes with PPARγ coactivator-1α(PGC-1α)/ERRα-dependent signaling:inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
- MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERR?
S Bae, MJ Lee, SH Mun, EG Giannopoul, V Yong-Gonza, JR Cross, K Murata, V Giguère, M van der Me, KH Park-Min
J. Clin. Invest., 2017;0(0):. - Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790.
Lanvin et al.
J.Biol.Chem., 2007;282:28328 - Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.
Kong et al.
Mol.Pharmacol., 2009;76:854 - Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand.
Willy et al.
Proc.Natl.Acad.Sci.USA, 2004;101:8912 - Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.
Theodoris et al.
Science., 2021;371
Citations for XCT 790
The citations listed below are publications that use Tocris products. Selected citations for XCT 790 include:
4 Citations: Showing 1 - 4
- The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.
Authors: Núria Et al.
Cell Metab 2021;33:379-394.e8 - Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC).
Authors: Michael P Et al.
Oncotarget 2015;6:25135-48 - Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.
Authors: Teng Et al.
Mol Cancer 2014;444:177 - Estrogen-related receptor α is required for efficient human cytomegalovirus replication.
Authors: Hwang Et al.
Proc Natl Acad Sci U S A 2014;111:E5706
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- 作者
- 内容
- 询问日期
文献和实验Tocris货号3928-10mg现货XCT 790上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Tocris货号3928-50mg现货XCT 790上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
Chemical Name:3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide
Purity:≥98%
Biological Activity
XCT 790 is a selective ERRα inverse agonist(IC50 = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10μM. Interferes with PPARγ coactivator-1α(PGC-1α)/ERRα-dependent signaling:inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
- MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERR?
S Bae, MJ Lee, SH Mun, EG Giannopoul, V Yong-Gonza, JR Cross, K Murata, V Giguère, M van der Me, KH Park-Min
J. Clin. Invest., 2017;0(0):. - Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790.
Lanvin et al.
J.Biol.Chem., 2007;282:28328 - Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.
Kong et al.
Mol.Pharmacol., 2009;76:854 - Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand.
Willy et al.
Proc.Natl.Acad.Sci.USA, 2004;101:8912 - Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.
Theodoris et al.
Science., 2021;371
Citations for XCT 790
The citations listed below are publications that use Tocris products. Selected citations for XCT 790 include:
4 Citations: Showing 1 - 4
- The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.
Authors: Núria Et al.
Cell Metab 2021;33:379-394.e8 - Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC).
Authors: Michael P Et al.
Oncotarget 2015;6:25135-48 - Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.
Authors: Teng Et al.
Mol Cancer 2014;444:177 - Estrogen-related receptor α is required for efficient human cytomegalovirus replication.
Authors: Hwang Et al.
Proc Natl Acad Sci U S A 2014;111:E5706
