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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Room Temperature
- 保质期：
1年
- 英文名：
Chel™-DE，EGTA
- 库存：
30⁺瓶
- 供应商：
上海睿安生物19121878899
- CAS号：
化学文摘社编号67-42-5
- 规格：
250g/瓶
Sigma货号E4378-250g现货EGTA乙二醇双(2-氨基乙基醚)四乙酸19121878899上海睿安生物
基本信息
中文名称: 乙二醇双(2-氨基乙基醚)四乙酸
中文别名:二胺四乙酸,Ethylene glycol-bis-(2-aminoethylether)-N,N,N′,N′-tetraacetic acid
英文名称:EGTA
英文别名: glycol-bis-(2-aminoethylether)-N,N,N′,N′-tetraacetic acid
线性分子式:[-CH2OCH2CH2N(CH2CO2H)2]2
纯度:99%
CAS号:67-42-5
分子式:C14H24N2O10
分子量:380.35
性状描述
白色结晶性粉末。溶于碱溶液，几乎不溶于水。
物理参数
熔点:241℃
用途说明
EGTA是最为被广泛使用的钙离子选择性的螯合剂，用于在镁存在下，测定钙。它与钙离子形成的复合物比与镁离子形成的复合物要稳定100,000倍,被用来制备钙缓冲液和控制钙离子的浓度。容量分析及光度分析中测量微量金属的络合剂、掩蔽剂。也可滴定钡、锶、铜、镁和锌。
RNA逆转录酶中RNA的脱氧测序缓冲器组分。
贮藏运输
密封保存。
说明
一般描述:在水中的溶解性随pH值增加而增加
应用:一种螯合剂，可在镁存在的情况下对钙进行测定。
乙二醇双(2-氨基(yǐ)醚)四乙酸(EGTA)可用于：
- 作为大鼠主动脉弓缩窄术(TAC)用低温心脏停跳液的组分
- 作为冰冷裂解缓冲液组分，用于蛋白提取和全细胞提取
- 作为HEK293F细胞线粒体提取用缓冲液A、B和C的组分
生化/生理作用:乙二醇双(2-氨基(yǐ)醚)四乙酸(EGTA)A是一种螯合剂，可在镁存在的情况下对钙进行测定。
同行评审论文(部分文献)
Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel.
Walter Marcotti et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(16), 5505-5514 (2014-04-18)
Tip links between adjacent stereocilia are believed to gate mechano-electrical transducer (MET) channels and mediate the electrical responses of sensory hair cells. We found that mouse auditory hair cells that lack tip links due to genetic mutations or exposure to
Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia.
David R Whitfield et al.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 23(2), 141-148 (2014-06-24)
Depression is a common symptom in dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), and Alzheimer disease (AD), yet its molecular basis remains unclear and current antidepressants do not appear to be effective. Cerebral zinc has been implicated in
SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression.
Anita C Bellail et al.
Nature communications, 5, 4234-4234 (2014-06-24)
Ubiquitination governs oscillation of cyclin-dependent kinase (CDK) activity through a periodic degradation of cyclins for orderly cell cycle progression; however, the mechanism that maintains the constant CDK protein levels throughout the cell cycle remains unclear. Here we show that CDK6
Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering.
Olof Idevall-Hagren et al.
The EMBO journal, 34(17), 2291-2305 (2015-07-24)
The extended synaptotagmins (E-Syts) are ER proteins that act as Ca(2+)-regulated tethers between the ER and the plasma membrane (PM) and have a putative role in lipid transport between the two membranes. Ca(2+) regulation of their tethering function, as well
Ocean plankton. Patterns and ecological drivers of ocean viral communities.
Jennifer R Brum et al.
Science (New York, N.Y.), 348(6237), 1261498-1261498 (2015-05-23)
Viruses influence ecosystems by modulating microbial population size, diversity, metabolic outputs, and gene flow. Here, we use quantitative double-stranded DNA (dsDNA) viral-fraction metagenomes (viromes) and whole viral community morphological data sets from 43 Tara Oceans expedition samples to assess viral
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文献和实验该产品被引用文献
Sigma货号E4378-250g现货EGTA乙二醇双(2-氨基乙基醚)四乙酸19121878899上海睿安生物
基本信息
中文名称: 乙二醇双(2-氨基乙基醚)四乙酸
中文别名:二胺四乙酸,Ethylene glycol-bis-(2-aminoethylether)-N,N,N′,N′-tetraacetic acid
英文名称:EGTA
英文别名: glycol-bis-(2-aminoethylether)-N,N,N′,N′-tetraacetic acid
线性分子式:[-CH2OCH2CH2N(CH2CO2H)2]2
纯度:99%
CAS号:67-42-5
分子式:C14H24N2O10
分子量:380.35
性状描述
白色结晶性粉末。溶于碱溶液，几乎不溶于水。
物理参数
熔点:241℃
用途说明
EGTA是最为被广泛使用的钙离子选择性的螯合剂，用于在镁存在下，测定钙。它与钙离子形成的复合物比与镁离子形成的复合物要稳定100,000倍,被用来制备钙缓冲液和控制钙离子的浓度。容量分析及光度分析中测量微量金属的络合剂、掩蔽剂。也可滴定钡、锶、铜、镁和锌。
RNA逆转录酶中RNA的脱氧测序缓冲器组分。
贮藏运输
密封保存。
说明
一般描述:在水中的溶解性随pH值增加而增加
应用:一种螯合剂，可在镁存在的情况下对钙进行测定。
乙二醇双(2-氨基(yǐ)醚)四乙酸(EGTA)可用于：
- 作为大鼠主动脉弓缩窄术(TAC)用低温心脏停跳液的组分
- 作为冰冷裂解缓冲液组分，用于蛋白提取和全细胞提取
- 作为HEK293F细胞线粒体提取用缓冲液A、B和C的组分
生化/生理作用:乙二醇双(2-氨基(yǐ)醚)四乙酸(EGTA)A是一种螯合剂，可在镁存在的情况下对钙进行测定。
同行评审论文(部分文献)
Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel.
Walter Marcotti et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(16), 5505-5514 (2014-04-18)
Tip links between adjacent stereocilia are believed to gate mechano-electrical transducer (MET) channels and mediate the electrical responses of sensory hair cells. We found that mouse auditory hair cells that lack tip links due to genetic mutations or exposure to
Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia.
David R Whitfield et al.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 23(2), 141-148 (2014-06-24)
Depression is a common symptom in dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), and Alzheimer disease (AD), yet its molecular basis remains unclear and current antidepressants do not appear to be effective. Cerebral zinc has been implicated in
SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression.
Anita C Bellail et al.
Nature communications, 5, 4234-4234 (2014-06-24)
Ubiquitination governs oscillation of cyclin-dependent kinase (CDK) activity through a periodic degradation of cyclins for orderly cell cycle progression; however, the mechanism that maintains the constant CDK protein levels throughout the cell cycle remains unclear. Here we show that CDK6
Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering.
Olof Idevall-Hagren et al.
The EMBO journal, 34(17), 2291-2305 (2015-07-24)
The extended synaptotagmins (E-Syts) are ER proteins that act as Ca(2+)-regulated tethers between the ER and the plasma membrane (PM) and have a putative role in lipid transport between the two membranes. Ca(2+) regulation of their tethering function, as well
Ocean plankton. Patterns and ecological drivers of ocean viral communities.
Jennifer R Brum et al.
Science (New York, N.Y.), 348(6237), 1261498-1261498 (2015-05-23)
Viruses influence ecosystems by modulating microbial population size, diversity, metabolic outputs, and gene flow. Here, we use quantitative double-stranded DNA (dsDNA) viral-fraction metagenomes (viromes) and whole viral community morphological data sets from 43 Tara Oceans expedition samples to assess viral
文献支持
Sigma货号E4378-250g现货EGTA乙二醇双(2-氨基乙基醚)四乙酸19121878899上海睿安生物
￥3963.03
