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- BioLegend
- 320806
- 美国
- 2025年08月18日
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
PE anti-human CD314 (NKG2D)
- 抗体英文名：
PE anti-human CD314 (NKG2D)
- 供应商：
上海善然生物科技有限公司
- 保存条件：
2-8℃
- 规格：
100tests
PE anti-human CD314 (NKG2D) Antibody
1D11
Catalog# / Size
320806 / 100 tests
Clone
Regulatory Status RUO
Other Names NKG2D
Isotype Mouse IgG1, κ
Description CD314 is a homodimeric C-type lectin-like protein also known as NKG2D. It is expressed on
NK cells, CD8 T cells, γ/δ T cells, and in vitro induced LAK cells. Several molecules have
been identified as the ligands for NKG2D, including MHC class-I chain-related protein A
(MICA), MICB, and UL16-binding proteins (ULBPs). NKG2D has no intrinsic signaling
capacity, but attains this by non-covalent association with DAP10 or DAP12 adaptors. In
addition to being a primary activation receptor on NK cells, NKG2D is also a costimulatory
receptor for TCR-mediated T cell proliferation and cytokine production. The interaction of
NKG2D with its ligands plays a role in the immune surveillance against pathogen and tumor
cells, and in the pathogenesis of autoimmune diseases.
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