- ￥8279
- BioLegend-HK
- 537302
- 美国
- 2025年07月13日
- 免疫荧光，流式
- 小鼠
- 人
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- 抗体名：
Purified anti-human IGFALS
- 抗体英文名：
Purified anti-human IGFALS
- 浓度：
0.5 mg/mL
- 应用范围：
免疫荧光，流式
- 宿主：
小鼠
- 供应商：
上海善然生物
- 库存：
4-5周
- 抗原来源：
小鼠
- 保质期：
2-3年左右
- 适应物种：
人
- 标记物：
Purified
- 克隆性：
单克隆
- 形态：
液体
- 规格：
500 μg
Purified anti-human IGFALS Antibody
M6005C04
Catalog# / Size 537302 / 500 µg
Clone
Regulatory Status RUO
Other Names ACLSD, ALS, insulin-like growth factor binding protein, acid labile subunit
Isotype Mouse IgG1, κ
Description The insulin-like growth factors (IGFs) are found in binary complexes with members of IGFbinding protein family (IGFBP-1 to -6). IGFALS is the acid-labile subunit of the IGF binding
protein complex that forms ternary complexes with IGFs and IGFBP-3/IGFBP-5. IGFALS has
no affinity for free IGFs and has a very low affinity for uncomplexed IGFBP-3/IGFBP-5, but
readily binds to the IGFs and IGFBP-3/IGFBP-5 complex, which extends the serum half-lives
of IGFs. IGFALS is mainly produced by the liver and is exclusively found in high concentration
in postnatal serum. IGFALS production is predominantly stimulated by the growth hormone.
Mutations in IGFALS causes ALS, amyotrophic lateral sclerosis, deficiency, which manifests
itself as delayed and slow puberty. IGFALS mutations have also been associated with insulin
resistance. Mature IGFALS protein is composed of 578 amino acids with 20 leucine-rich
repeats. It shares 93% identity between mouse and rat, and 79% between mouse and human.
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Recombinant protein
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C.
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