- ￥380 - 1330
- Solarbio|ActivAb
- 北京
- CLP1364
- 2025年07月29日
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- 详细信息
- 技术资料
- 保存条件：
Store at -20℃，2 years.(Avoid freeze/thaw cycles)
- 保质期：
Store at -20℃，2 years.(Avoid freeze/thaw cycles)
- 英文名：
PKI 14-22 amide，myristoylated
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
10mg/5mg/1mg
| 规格： | 10mg | 产品价格： | ￥1330.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥950.0 |
| 规格： | 1mg | 产品价格： | ￥380.0 |
| 基本信息 | |
| 产品类型 | 多肽 |
| CAS | No.23815-89-6 |
| 单字母序列 | RPPGF |
| 三字母序列 | Arg-Pro-Pro-Gly-Phe |
| 别名 | 1-5-血管舒缓激肽;Bradykinin(1-5) |
| 分子式 | C27H40N8O6 |
| 分子量 | 572.67 |
| 纯度 | ≥95% |
| 外观(性状) | 冻干粉;Lyophilized powder |
| 溶解性 | DMSO：100 mg/mL; *超声助溶; |
| 盐体系 | TFA盐;Trifluoroacetate salt |
| 来源 | 合成;Synthetic |
| 储存条件 | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 类别/标签 | 心血管研究(Cardiovascular research) |
| 规格 | Bradykinin (1-5) 是 Bradykinin 的主要稳定代谢物，由血管紧张素转换酶 (ACE) 经蛋白水解作用形成。Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE). |
| In Vitro | 未检测 |
| In Vivo | Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (Pthrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED50 of 183±2 pmol/min. |
| 单位 | 瓶 |
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CLP1364 KRFK 底物和酶抑制剂 201422-03-9
￥380 - 1330
