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- Solarbio
- 北京
- IB1540
- 2026年08月13日
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- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Benztropine Mesylate
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
132-17-2
- 规格：
500mg/1g
| 规格： | 500mg | 产品价格： | ¥390.00 |
|---|---|---|---|
| 规格： | 1g | 产品价格： | ¥490.00 |
| CAS | 132-17-2 |
| 中文名称 | 甲磺酸苯扎托品 |
| 英文名称 | Benztropine Mesylate |
| 别名 | 苯甲托品甲烷磺酸盐 |
| 分子式 | C21H25NO·CH4SO3 |
| 分子量 | 403.54 |
| 规格 | 1g ; 500mg |
| 溶解性 | Soluble in Water/DMSO ≥5mg/mL |
| 纯度 | ≥98% |
| 外观(性状) | White to light yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷藏运输 |
| EC | EINECS 205-048-8 |
| MDL | MFCD00074784 |
| SMILES | CN1[C@@H]2CC[C@H]1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4.CS(=O)(=O)O |
| InChIKey | CPFJLLXFNPCTDW-IIPFOPBBSA-N |
| InChI | InChI=1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2，3)4/h2-11，18-21H，12-15H2，1H3;1H3，(H，2，3，4)/t18-，19+，20?; |
| PubChem CID | 3246155 |
| 靶点 | mAChR |
| 通路 | Neuronal Signaling;GPCR & G Protein |
| 背景说明 | 是抗毒蕈碱的化合物,可用于帕金森病的相关研究。 |
| 生物活性 | Benztropine mesylate inhibits functions of CSCs via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors. [1] |
| In Vitro | Benztropine mesylate(0.1-10 μM; 72 hours)treatment inhibits the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM. In MDA-MB-231 cells and 4T1-luc2 cells，Benztropine mesylate reduces the size as well as the number of mammospheres significantly in a dose-dependent manne[1].Benztropine mesylate inhibits functions of cancer stem cells(CSCs)via the acetylcholine receptors，dopamine transporters/receptors，and/or histamine receptors[1].Benztropine mesylate induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced re-myelination[1]. |
| In Vivo | Benztropine mesylate(1.5 mg/kg; daily; for 3 weeks; Balb/c mice)treatment significantly reduces both tumor size and tumor weight in a 4T1 mouse model[1]. |
| 动物实验 | Mice were housed in microisolator cages and in pathogen free conditions. Surgical procedures were performed under anesthesia and all efforts were made to minimize suffering of the animals. 4T1-luc2 spheres were maintained in ultra-low attachment plates with SCM and pretreated for 6 days with benztropine mesylate (5 μM) or DMSO (0.1%) in vitro. Single cells were injected in 50 μl 1:1 matrigel:DMEM/F12 solution into the fourth mammary fat pad of 8-week old female Balb/c mice (Janvier) at varying cell numbers ranging from 10 to 1，000 cells/mouse [1]. |
| 数据来源文献 | [1]. Jihong Cui， et al. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 3;8(1):1007-1022. |
| 单位 | 瓶 |
| 表格1 | |*|1mg|5mg|10mg|$$|1mM|2.4781mL|12.3903mL|24.7807mL|$$|5mM|0.4956mL|2.4781mL|4.9561mL|$$|10mM|0.2478mL|1.239mL|2.4781mL| |
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甲磺酸苯扎托品
¥390 - 490
