PerCP/Cyanine5.5 anti-GATA3

PerCP/Cyanine5.5 anti-GATA3 Antibody
W19195B
Catalog# / Size 386909 / 25 tests
386910 / 100 tests
Clone
Regulatory Status RUO
Other Names GATA-binding factor 3, trans-acting T-cell-specific transcription factor GATA-3
Isotype Rat IgG2a, κ
Description GATA3 functions as a major regulator of T helper 2 (Th2) cell differentiation in immune cells.
GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediated pathway,
which results in production of IL-4, IL-5, and IL-13 cytokines. This is responsible for the
preferential differentiation of Th2-cells. GATA3 has been shown to regulate early developmental
processes of T cells, such as T cell commitment, positive selection, and post-commitment CD4+ T
cell survival. In the mammary gland, GATA3 plays an important role in differentiation and
commitment of luminal epithelial cells. In a mouse model, exogenous expression of GATA3 in
undifferentiated breast carcinoma cells induces differentiation and suppresses spreading of the
tumor cells, suggesting that GATA3 is involved in preventing malignancy of breast cancer. GATA3
has been reported to be essential in the development of a variety of normal tissues. Defects in
GATA3 result in hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR
syndrome).
Product Details
Verified Reactivity Human, Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Partial human GATA3 recombinant protein (1-258 aa)
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under
optimal conditions.
Concentration Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our
Certificate of Analysis online tool.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged
exposure to light. Do not freeze.