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- 技术资料
- 抗体名:
Brilliant Violet 785™ anti-human CD274 (B7-H1, PD-L1)
- 抗体英文名:
Brilliant Violet 785™ anti-human CD274 (B7-H1, PD-L1)
- 应用范围:
免疫荧光,流式
- 宿主:
小鼠
- 供应商:
上海善然生物
- 库存:
现货
- 抗原来源:
小鼠
- 适应物种:
Human Reported Reactivity African Green, Baboon, Cynomolgus, Rhesus
- 标记物:
Brilliant Violet 785™
- 克隆性:
单克隆
- 形态:
液体
- 规格:
100 tests
Brilliant Violet 785™ anti-human CD274 (B7-H1, PD-L1) Antibody
29E.2A3
Catalog# / Size 329735 / 25 tests
329736 / 100 tests
Clone
Regulatory Status RUO
Other Names Programmed cell death ligand 1 (PD-L1), B7 homolog 1 (B7-H1)
Isotype Mouse IgG2b, κ
Description CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as
a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the
stimulatory and inhibitory signals needed for responses to microbes and maintenance of selftolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ
production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown
that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance
T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising
interesting implications for its expression in a wide variety of cell types, including T and B cells,
antigen-presenting cells, and nonhematopoietic cells.
Product Details
Verified Reactivity Human
Reported Reactivity African Green, Baboon, Cynomolgus, Rhesus
Antibody Type Monoclonal
Host Species Mouse
Immunogen Full length human PD-L1
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 785™
under optimal conditions.
Concentration Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our
Certificate of Analysis online tool.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from
prolonged exposure to light. Do not freeze.
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Vybrant® DyeCycle Violet Stain
Fluor® 488 and PE channels Eliminate or correct for cell aggregates during data analysis using gating or modeling software Human and rodent stem cells efflux Vybrant® DyeCycle™ Violet stain, and this is the basis for the Side Population
,PD-1/PD-L1这么值钱,大家一定好奇它到底是什么鬼。 PD-1全名是程序性死亡分子1(programmed death-1)是Ishida等[1]通过消减杂交技术于1992年发现的[2],是CD28家族成员,胞质区含有2个酪氨酸残基,1个位于靠近N端的免疫受体酪氨酸抑制基序(ITIM)中,另一个1个位于靠近C端的免疫受体酪氨酸转化基序(ITSM)中[2]。 PD-L1(CD274)是B7家族成员,是PD-1的配体,属于1型跨膜蛋白,全长290个氨基酸,包含1个IgV样
LIVE/DEAD® Violet Viability/Vitality Kit
. Material Amount Storage Stability CellTrace™ calcein violet stain, lyophilized (Component A) *
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