InvivoCrown In vivo NK cell de

InVivoPro Anti-Mouse TNFα in vivo antibody, Clone TN3-19.12InVivoPro Anti-Mouse NK1.1(CD161) Antibody in vivo antibody, Clone PK136Armenian Hamster IgGMouse IgG2a κTN3-19.12PK136TNFαNK1.1TNF-alpha, TNFSF2, Tnlg1fCD161 antigen, CD161, CD161/NK1.1Armenian Hamster IgG Isotype ControlMouse IgG2a Isotype ControlPBS, pH 7.2, contains no stabilizers or preservativesPBS, pH 7.2, contains no stabilizers or preservativesMouseMouseArmenian HamsterMouse200-500 μg per mouse; or 10-20 mg/kg. This range is based off the most recent publication data using the TN3-19.12 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.200-500 μg per mouse; or 10-20 mg/kg. This range is based off the most recent publication data using the PK136 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.12267Dudek, Michael et al. "Auto-aggressive CXCR6+ CD8 T Cells Cause Liver Immune Pathology in NASH",Nature (2022) Gulen, Muhammet F. et al. "Cgas–sting Drives Ageing-Related Inflammation and Neurodegeneration",Nature 620.7973 (2023): 374-380. Ma, Leyuan et al. "Vaccine-boosted CAR T Crosstalk with Host Immunity to Reject Tumors with Antigen Heterogeneity",Cell (2023)Andre, Pascale et al. "Anti-NKG2A Mab is a Checkpoint Inhibitor That Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells",Cell 175.7 (2018): 1731-+. Biswas, Subir et al. "IgA Transcytosis and Antigen Recognition Govern Ovarian Cancer Immunity.",Nature 591.7850 (2021): 464-470. Deng, Zihou et al. "The Nuclear Factor ID3 Endows Macrophages with a Potent Anti-Tumour Activity",NATURE 626.8000 (2024)The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity. It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites. TNF-alpha is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-alpha secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-alpha has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-alpha.NK-1.1 surface antigen, also known as CD161b/CD161c, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.In vivo TNFα neutralization, Enzyme-linked Immunosorbent AssayIn vivo NK cell depletion, Flow cytometryprotein A or Gprotein A or GThis antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.2-8°C with blue ice2-8°C with blue iceLot specific, generally ≥ 5.0 mg/mlLot specific, generally ≥ 5.0 mg/ml12 months from the date of receipt if stored as recommended12 months from the date of receipt if stored as recommendedPBS Buffer, PH 7.2, with no carrier protein, or preservatives.PBS Buffer, PH 7.2, with no carrier protein, or preservatives.0.2 μM filtered0.2 μM filtered≤ 1.0 EU/mg, by the LAL method≤ 1.0 EU/mg, by the LAL method0.990.99可替换BioXCell产品货号为BE0036