Alexa Fluor® 488 anti-mouse CD

Alexa Fluor® 488 anti-mouse CD206 (MMR) Antibody
C068C2
Catalog# / Size 141709 / 25 µg
141710 / 100 µg
Clone
Regulatory Status RUO
Other Names MMR (macrophage mannose receptor), MR (mannose receptor), MRC1
Isotype Rat IgG2a, κ
Description CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern
recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on
macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR
recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine
through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens
through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates
endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays
an important role in host defense and provides a link between innate and adaptive immunity.
Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a
contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in
controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.
Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Recombinant mouse CD206 (MMR)
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal
conditions.
Concentration 0.5 mg/mL
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged
exposure to light. Do not freeze