HCC1954

HCC1954/HCC1954细胞系/HCC1954细胞株/HCC1954人乳腺导管癌细胞

Cell line name HCC1954

Synonyms HCC-1954; Hamon Cancer Center 1954

Accession CVCL_1259

Resource Identification Initiative To cite this cell line use: HCC1954 (RRID:CVCL_1259)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: JWGray breast cancer cell line panel.

Part of: ICBP43 breast cancer cell line panel.

Part of: KuDOS 95 cell line panel.

Part of: MD Anderson Cell Lines Project.

Population: East Indian.

Doubling time: 45 hours (PubMed=25984343); 43.81 hours (JWGray panel).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: H2BK120ub ChIP-seq epigenome analysis.

Omics: H3K23ac ChIP-seq epigenome analysis.

Omics: H3K27ac ChIP-seq epigenome analysis.

Omics: H3K27me3 ChIP-seq epigenome analysis.

Omics: H3K36me3 ChIP-seq epigenome analysis.

Omics: H3K4me1 ChIP-seq epigenome analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: H3K79me2 ChIP-seq epigenome analysis.

Omics: H3K9ac ChIP-seq epigenome analysis.

Omics: H3K9me3 ChIP-seq epigenome analysis.

Omics: H4K8ac ChIP-seq epigenome analysis.

Omics: CNV analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Glycoproteome analysis by proteomics.

Omics: Hi-C chromosome conformation analysis.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Breast; UBERON=UBERON_0000310.

Sequence variations

Gene fusion; HGNC; 2092; CLTC + HGNC; 29559; VMP1; Name(s)=CLTC-VMP1 (PubMed=23637631).

Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (ATCC=CRL-2338).

Mutation; HGNC; 11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (PubMed=28889351; ATCC=CRL-2338).

HLA typing Source: PubMed=25960936

Class I

HLA-A A*24:02,24:02

HLA-B B*35:01,40:06

HLA-C C*04:01,15:02

Class II

HLA-DQ DQA1*03:02,01:02

HLA-DR DRB1*16:05,16:05

 

Source: PubMed=26589293

Class I

HLA-A A*24:02,24:02

HLA-B B*35:01,40:06

HLA-C C*04:01,15:02

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0.47

Native American 0

East Asian, North 5.83

East Asian, South 0

South Asian 78.3

European, North 2.65

European, South 12.74

Disease Breast ductal carcinoma (NCIt: C4017)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Children:

CVCL_LG20 (HCC1954-LR) CVCL_4W93 (HCC1954-Luc) CVCL_LG21 (HCC1954-NR)

CVCL_VR24 (HCC1954-TGL) CVCL_B3MM (HCC1954/TDR)

Originate from same individual CVCL_1260 ! HCC1954 BL

Sex of cell Female

Age at sampling 61Y

Category Cancer cell line

STR profile Source(s): ATCC=CRL-2338; Cosmic-CLP=749709; PubMed=25877200; PubMed=28889351; Technion Genomics Center

 

Markers:

Amelogenin X

CSF1PO 10

D1S1656 15,16

D2S441 10,11

D2S1338 17,26

D3S1358 15,16

D5S818 11

D7S820 10,11

D8S1179 12,15

D10S1248 14,15

D12S391 22

D13S317 8,9

D16S539 9,11

D18S51 14,18

D19S433 13,15.2

D21S11 28,32.2

D22S1045 11,15

FGA 22,23

Penta D 9,12

Penta E 12,16

TH01 6,7

TPOX 8,9

vWA 18,19

 

 

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