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- 文献和实验
- 技术资料
- 英文名:
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- 库存:
现货库存
- 供应商:
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- 肿瘤类型:
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- 细胞类型:
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- 品系:
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- 组织来源:
ATCC/DSMZ/ECACC
- 相关疾病:
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- 物种来源:
人或动物
- 免疫类型:
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- 细胞形态:
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- 是否是肿瘤细胞:
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- 器官来源:
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- 运输方式:
常温或干冰
- 年限:
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- 生长状态:
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| 种属 | 人 |
| 别称 | MOLM13; Molm13; Molm 13 |
| 组织来源 | 外周血 |
| 疾病 | 急性髓细胞白血病 |
| 传代比例/细胞消化 | 1:2传代 |
| 完全培养基配置 | RPMI1640 培养基;15%胎牛血清;1%双抗 |
| 简介 | 该细胞是从一名20岁急性髓系白血病患者的外周血中建立 ,该患者在最初的骨髓增生异常综合征后于1995年复发 (MDS ,成纤维细胞过多的难治性贫血 ,RAEB) ;携带FLT3的内部串联复制;FLT3蛋白不表达;细胞系携带cell外显 子8突变体;MOLM-14姊妹细胞系(ACC 777)。外显子组和核糖核酸序列数据可用(见参考文献18187和外胚层序列 和RNA-Seq) |
| 形态 | 圆形 |
| 生长特征 | 悬浮生长 |
| 倍增时间 | ~50h |
| STR | Amelogenin X,Y CSF1PO 10 D2S1338 23,25 D3S1358 15 D5S818 10,11 D7S820 10,12 D8S1179 13,14 D13S317 10,11 D16S539 10,11 D18S51 13,15 D19S433 12,14 D21S11 30,31 FGA 21,23 Penta D 9,12 Penta E 18,19 TH01 7 TPOX 8 vWA 16,17 |
| 保藏机构 | DSMZ; ACC-554 |
Suster DI , Mino⁃Kenudson M. Molecular pathology of primary non⁃ observed reduced numbers of CD8+ and increased numbers of CD4+ T cells in the bone marrow and spleen of young and aged SHP2-D61Y-mutant mice as well as in Influenza A Virus (IAV)-infected mice compared to controls. In addition, we found elevated frequencies of effector memory CD8+ T cells and an upregulation of the programmed cell death protein 1 (PD-1)-receptor on both CD4+ and CD8+ T cells. Functional analysis of SHP2-D61Y-mutated T cells revealed an induction of late apoptosis/necrosis, a reduced proliferation and altered signaling upon TCR stimulation. However, the ability of D61Y-mutant mice to clear viral infection was
[2] Broderick SR.Adjuvant and neoadjuvant immunotherapy in non⁃small immunoediting describes the process whereby highly immunogenic tumor cells are removed, or edited, from the primary tumor repertoire by the immune system. In immunodeficient mice, the editing process is hampered, and unedited tumor cells can be recovered and studied. In this study,
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文献和实验/Suster DI , Mino⁃Kenudson M. Molecular pathology of primary non⁃
[2] Broderick SR.Adjuvant and neoadjuvant immunotherapy in non⁃small
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