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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD314 (NKG2D)
- 级别：
CD314 (NKG2D) Antibody
- 目录编号：
CD314 (NKG2D) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
CD314 (NKG2D) Antibody
- 抗体英文名：
Brilliant Violet 421™ anti-human CD314 (NKG2D) Antibody
- 抗体名：
CD314 (NKG2D) Antibody
- 标记物：
CD314 (NKG2D) Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
CD314 (NKG2D) Antibody
- 亚型：
CD314 (NKG2D) Antibody
- 形态：
CD314 (NKG2D) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
CD314 (NKG2D) Antibody
- 规格：
25 tests/100 tests
| 规格： | 25 tests | 产品价格： | ￥3700.0 |
|---|---|---|---|
| 规格： | 100 tests | 产品价格： | ￥7700.0 |
Description ：CD314 is a homodimeric C-type lectin-like protein also known as NKG2D. It is expressed on NKcells, CD8 T cells, γ/δ T cells, and in vitro induced LAK cells. Several molecules have beenidentified as the ligands for NKG2D, including MHC class-I chain-related protein A (MICA),MICB, and UL16-binding proteins (ULBPs). NKG2D has no intrinsic signaling capacity, butattains this by non-covalent association with DAP10 or DAP12 adaptors. In addition to being aprimary activation receptor on NK cells, NKG2D is also a costimulatory receptor for TCRmediated T cell proliferation and cytokine production. The interaction of NKG2D with its ligandsplays a role in the immune surveillance against pathogen and tumor cells, and in thepathogenesis of autoimmune diseases.
Verified Reactivity ：Human
Reported Reactivity ：African Green, Baboon, Cynomolgus, Rhesus
Antibody Type ：Monoclonal
Host Species ：Mouse
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation ：The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™under optimal conditions.
Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.
Excitation Laser ：Violet Laser (405 nm)
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文献和实验1. Wu J, et al. 1999. Science 285:730.
2. Wu J, et al. 2000. J. Exp. Med. 192:1059.
3. Groh V, et al. 2001. Nature Immunol. 2:255.
4. Wu J, et al. 2002. J. Immunol. 169:1236.
5. Roberts A, et al. 2001. J. Immunol. 167:5527.
6. Groh V, et al. 2003. Proc. Natl. Acad. Sci. USA 100:9452.
7. Kraetzel K et al. 2008. Eur. Respir. J. 32:563. PubMed
8. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed
9. Watanbe M, et al. 2014. Int Immunol. PubMed
Product Citations：
1. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
2. Alonso R, et al. 2022. Blood Adv. :. PubMed
3. Nahi H, et al. 2022. Cell Rep Med. 3:100508. PubMed
4. Harris LD, et al. 2020. Front Cell Infect Microbiol. 10:120. PubMed
5. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
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