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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD140b (PDGFRβ)
- 级别:
CD140b (PDGFRβ) Antibody
- 目录编号:
CD140b (PDGFRβ) Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
CD140b (PDGFRβ) Antibody
- 抗体英文名:
Purified anti-human CD140b (PDGFRβ) Antibody
- 抗体名:
CD140b (PDGFRβ) Antibody
- 标记物:
CD140b (PDGFRβ) Antibody
- 宿主:
小鼠
- 适应物种:
人
- 免疫原:
CD140b (PDGFRβ) Antibody
- 亚型:
CD140b (PDGFRβ) Antibody
- 形态:
CD140b (PDGFRβ) Antibody
- 应用范围:
FC
- 保存条件:
2-8℃
- 浓度:
0.5 mg/ml
- 规格:
100 µg
Description :CD140b is a cell surface tyrosine kinase receptor for members of the platelet-derived growthfactor family. The identity of the growth factor bound to the receptor determines whether thefunctional receptor is a homodimer or heterodimer composed of both PDGFR-α and -β.CD140b contains two immunoglobulin-like domains and a tyrosine kinase domain with apredicted molecular weight approximately 124 kD. CD140b is widely expressed on a variety ofmesenchymal-derived cells and is preferentially expressed on some tumors such asmedulloblastoma. Binding of B-chain containing PDGF molecules can stimulate cellproliferation. CD140b has been shown to interact with a number of kinases (including Raf-1,NCK1, FAK, Fyn, others) as well as adaptor molecules and signaling intermediates (Crk, Grb2,Grb4, RasGAP, SHP2, SHC1, others), and has also been shown to associate with integrin β3and nexin sorting molecules. CD140b has been implicated in several disease states includingatherogenesis and oncogenesis. The PDGFRβ is heavily phosphorylated on numeroustyrosine residues through both autophosphorylation and ligand-dependent processes.
Verified Reactivity :Human
Reported Reactivity :African Green, Baboon, Cynomolgus, Rhesus
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :NIH-3T3 cells transfected with human PDGFRbeta
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation :The antibody was purified by affinity chromatography.
Concentration :0.5 mg/ml
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C.
Application :FC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
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文献和实验1. Vogel W, et al. 2002. Haematologica 88:126.
2. Arima, S., et al 2011. Development. 138:4763. PubMed.
Product Citations:
1. Batth IS, et al. 2020. BMC Cancer. 20(1):715. PubMed
2. Arima S, et al. 2011. Development. 138:4763. PubMed
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