BioLegend 687103 Go-ChIP-Grade

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BioLegend 687103 Go-ChIP-Grade™ Purified anti-Ikaros
产品简介：
产品品牌：BioLegend
产品货号：687103
产品名称：BioLegend 687103 Go-ChIP-Grade™ Purified anti-Ikaros
产品规格：25 µg

产品说明：
Clone   16B5C71 (See other available formats)
Regulatory Status   RUO
Other Names   IK1, IKZF1
Isotype   Mouse IgG2a, κ

描述
Ikaros，也称为IKZF1，属于锌指DNA结合蛋白家族，调节淋巴细胞分化。它有能力与Ikaros家族的其他成员形成同二聚体和异二聚体，包括Aiolos和Helios。Ikaros可在大多数胎儿和成人造血细胞类型上发现，如T细胞和B细胞、自然杀伤细胞（NK）、单核细胞/巨噬细胞和树突状细胞。Ikaros是一种肿瘤抑制因子，据报道其在几种白血病中不存在或表达减少。
Ikaros, also known as IKZF1, belongs to a family of zinc-finger DNA-binding proteins that regulate lymphocyte differentiation. It has the ability to form homo- and heterodimers with other members of the Ikaros family, which include Aiolos and Helios. Ikaros can be found on a majority of fetal and adult hematopoietic cell types such as T- and B-cells, natural killer cells (NKs), monocytes/macrophages, and dendritic cells. Ikaros is a tumor suppressor and its absence or reduced expression has been reported in several leukemias.

Product Details
Isotype Control
Go-ChIP-Grade™ Purified Mouse IgG2a, κ Isotype Ctrl
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen
Human Ikaros peptide (431-477 aa) conjugated to KLH Freund's adjuvant.

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation
The antibody was purified by affinity chromatography.
Concentration   0.5 mg/mL

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application   ChIP - Quality tested
WB - Verified

Recommended Usage
Each lot of this antibody is quality control tested by ChIP assay. The recommended starting antibody to chromatin ratio is 4 µg of antibody and 5 µg of chromatin per IP. Optimal antibody to chromatin ratio should be determined by the end user. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per mL. It is recommended that the reagent to be titrated for optimal performance before each experiment.

Antigen Details
Structure
Zinc-finger DNA binding protein, homo/heterodimer, 57.5 kD
Distribution   Fetal and adult hematopoietic cells.
Function   Regulates lymphocyte differentiation.
Interaction   DNA.
Cell Type   B cells, Dendritic cells

Biology Area
Cell Biology, Chromatin Remodeling/Epigenetics, Immunology, Signal Transduction, Transcription Factors
Molecular Family   Nuclear Markers

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