BioLegend 666409 Alexa Fluor®

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BioLegend 666409 Alexa Fluor® 647 anti-STAT1 Phospho (Tyr701)
产品简介：
产品品牌：BioLegend
产品货号：666409
产品名称：BioLegend 666409 Alexa Fluor® 647 anti-STAT1 Phospho (Tyr701)
产品规格：25 tests

产品说明：
Clone   A17012A (See other available formats)
Regulatory Status   RUO
Other Names
Signal Transduced Activator of Transcription 1, Transcription Factor ISGF-3 components p91/p84
Isotype   Mouse IgG1, κ

描述
STAT1，也称为信号转导和转录激活因子1，是一种普遍表达的细胞质蛋白，并在细胞因子信号传导中被激活，包括IFN-α、IFN-γ、EGF、PDGF和IL-6。激活后，STAT1在酪氨酸701（Tyr701）被受体相关激酶磷酸化，包括JAK1、JAK2和TYK2。这导致STAT1二聚化并随后易位到细胞核，在那里它作为转录激活剂发挥作用。STAT1参与IFN介导的免疫反应，STAT1缺陷小鼠对细菌和病毒感染高度敏感。
STAT1, also known as signal transduction and activator of transcription 1, is a ubiquitously expressed cytoplasmic protein and is activated in response to cytokine signaling, including IFN-α, IFN-γ, EGF, PDGF, and IL-6. Upon activation, STAT1 is phosphorylated at Tyrosine 701 (Tyr701) by receptor-associated kinases, including JAK1, JAK2, and TYK2. This results in STAT1 dimerization and subsequent translocation to the nucleus, where it functions as a transcriptional activator. STAT1 is involved in IFN-mediated immune responses, and STAT1-deficient mice are highly sensitive to bacterial and viral infections.

Product Details
Isotype Control
Alexa Fluor® 647 Mouse IgG1, κ Isotype Ctrl (ICFC)
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   ICFC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Phos™ Perm Buffer in Cell Suspensions Protocol. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.

Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

Antigen Details
Structure
Two isoforms of STAT1 exist as a result of alternative splicing. Isoform α is a 750 amino acid protein with a predicted molecular weight of 87 kD; the β isoform is a 712 amino acid protein with a predicted molecular weight of 83 kD.

Distribution
Ubiquitous tissue expression, nucleoplasmic-cytosolic distribution
Function   Immune response activation, cell signaling

Interaction
STAT1, STAT2, IRF9, ERBB4, JAK1, JAK2, TYK2, TNK1, SHP2
Biology Area   Cell Biology
Molecular Family   Nuclear Markers, Phospho-Proteins

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