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- 文献和实验
- 技术资料
- 库存:
99
- 英文名:
Alexa Fluor® 647 anti-Nanog
- 供应商:
北京云肽生物科技有限公司
北京云肽生物科技有限公司作为 BioLegend 的特约经销商,为广大客户提供原装正品,货期短,折扣好的服务准则。
美国 BioLegend 公司位于美国加州,致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长,但它聚集了一批来自 PharMingen 公司的专业人士,建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势,以及与世界知名实验室和研究所的良好合作关系,以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证,提供各种质量卓越的产品,并不断地开发新产品,以满足飞速发展的生命科学研究的需要。
BioLegend 674010 Alexa Fluor® 647 anti-Nanog
产品简介:
产品品牌:BioLegend
产品货号:674010
产品名称:BioLegend 674010 Alexa Fluor® 647 anti-Nanog
产品规格:100 µg
产品说明:
Clone 23D2-3C6 (See other available formats)
Regulatory Status RUO
Other Names
Homeobox Transcription Factor Nanog, Nanog Homeobox, Homeobox Protein NANOG, Homeobox Transcription Factor Nanog-Delta 48
Isotype Mouse IgG1, κ
描述
Nanog是一种转录因子,在维持胚胎干细胞的多能性和自我更新中起着关键作用。Nanog的表达受到其他转录因子的调节,这些转录因子包括Sox2和Oct-4。它也在上皮恶性肿瘤中发挥作用,并在癌症干细胞中富集。纳米的消融足以减少癌症干细胞池。
Nanog is a transcription factor that plays key roles in the maintenance of pluripotency and self-renewal in embryonic stem cells. Nanog expression is regulated by other transcription factors, which include Sox2 and Oct-4. It also plays a role in epithelial malignancy and is enriched in cancer stem cells. The ablation of nanog is sufficient to reduce the cancer stem cell pool.
Product Details
Isotype Control
Alexa Fluor® 647 Mouse IgG1, κ Isotype Ctrl (ICFC)
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen
Full length human recombinant protein expressed in bacteria
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application ICFC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear™ Transcription Factor Staining Protocol.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
Antigen Details
Structure
305 amino acids with a predicted molecular weight of approximately 35 kD.
Distribution
Nuclear and cytoplasmic. Expressed by embryonic stem (ES) cells or cancer stem cells. Expression decreases with ES differentiation.
Function
Transcription regulator that plays key roles in the maintenance of pluripotency and self-renewal in embryonic stem cells.
Interaction
Interacts with SMAD1, SALL4, and ZNF281/ZFP281.
Cell Type Embryonic Stem Cells
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Signal Transduction, Stem Cells, Transcription Factors
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