BioLegend 650804 Alexa Fluor®

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BioLegend 650804 Alexa Fluor® 488 anti-Histone H3 Phospho (Ser10)
产品简介：
产品品牌：BioLegend
产品货号：650804
产品名称：BioLegend 650804 Alexa Fluor® 488 anti-Histone H3 Phospho (Ser10)
产品规格：100 tests

产品说明：
Clone   11D8 (See other available formats)
Regulatory Status   RUO
Other Names   Histone-H3, H3
Isotype   Mouse IgG2b, κ

描述
组蛋白H3在有丝分裂过程中在丝氨酸10处磷酸化，并被发现通过Aurora激酶和NIMA激酶的作用参与细胞分裂过程中的转录激活、染色质去凝聚和染色体压实。
Histone H3 is phosphorylated at serine 10 during mitosis and is found to be involved in transcriptional activation, chromatin decondensation, and chromosome compaction during cell division, by the action of Aurora kinase and NIMA kinases.

Product Details
Isotype Control   Alexa Fluor® 488 Mouse IgG2b, κ Isotype Ctrl
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen   Modified synthetic peptide conjugated to KLH

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   ICFC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent intracellular staining with flow cytometric analysis. Please follow the Cell Fixation and Permeabilization Protocol Using 70% Ethanol. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.

Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

Antigen Details
Structure
H3 is part of the nucleosome, comprised of an octameric complex with H2A, H2B, and H4 proteins.
Distribution   Nucleus

Function
H3 is a core component of the nucleosome that serves to wrap and compact DNA into chromatin. Histones, therefore, limit the accessibility of DNA, providing mechanisms for transcription regulation, DNA repair and replication, and chromosomal stability.

Interaction
Two molecules of H3 form a heterotetramer with two molecules of H4.

Biology Area
Cell Biology, Chromatin Remodeling/Epigenetics, DNA Repair/Replication, Transcription Factors
Molecular Family    Phospho-Proteins

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