BioLegend 648304 PE anti-mouse

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BioLegend 648304 PE anti-mouse/human Bcl-6
产品简介：
产品品牌：BioLegend
产品货号：648304
产品名称：BioLegend 648304 PE anti-mouse/human Bcl-6
产品规格：100 tests

产品说明：
Clone  IG191E/A8 (See other available formats)
Regulatory Status  RUO
Other Names
B-cell lymphoma 6, BCL-5, LAZ3, BCL6A, ZNF51, ZBTB27
Isotype   Mouse IgG1

描述
B细胞淋巴瘤6（Bcl-6）是一种80kD同源二聚体，属于BTB-POZ锌指家族。它由一个BTB（POZ）结构域和六个C2H2型锌指组成。Bcl-6是一种转录抑制因子，也是生发中心反应的主要调控因子。在B细胞上，Bcl-6诱导增殖、抗体类别转换和亲和力成熟，同时抑制其向浆细胞的分化。在T细胞上，Bcl-6诱导其分化为TFH。这种分子也在一些B细胞淋巴瘤和癌症细胞中表达。
B-cell lymphoma 6 (Bcl-6), is an 80 kD homodimer and member of the BTB-POZ zinc finger family.  It consists of one BTB (POZ) domain and six C2H2-type zinc fingers. Bcl-6 is a transcriptional repressor as well as a master regulator of germinal center reaction. On B cells, Bcl-6 induces proliferation, antibody class switching and affinity maturation, while inhibits its differentiation to plasma cells. On T cells, Bcl-6 induces its differentiation to TFH. This molecule is also expressed in some B cell lymphomas and breast cancer cells.

Product Details
Isotype Control   PE Mouse IgG1, κ Isotype Ctrl (FC)
Verified Reactivity   Human, Mouse
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen
Plasmid vector containing cDNA of the Bcl-6 gene

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   ICFC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Antigen Details
Structure
Member of the BTB-POZ zinc finger family, 80 kD, homodimer, 1 BTB (POZ) domain, 6 C2H2-type zinc fingers

Distribution
Germinal center B cells, follicular helper T cells (TFH), B cell lymphomas, breast cancer cells

Function
Transcription factor, master regulator of germinal center reaction
Interaction   BLIMP-1
Cell Type   B cells, Tfh
Biology Area
Cell Biology, Immunology, Transcription Factors
Molecular Family   Nuclear Markers

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