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- 文献和实验
- 技术资料
- 库存：
99
- 英文名：
Alexa Fluor® 647 anti-PARP
- 供应商：
北京云肽生物科技有限公司
BioLegend 614308 Alexa Fluor® 647 anti-PARP
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 614308 Alexa Fluor® 647 anti-PARP
产品简介：
产品品牌：BioLegend
产品货号：614308
产品名称：BioLegend 614308 Alexa Fluor® 647 anti-PARP
产品规格：100 µg
产品说明：
Clone 5A5 (See other available formats)
Regulatory Status RUO
Other Names Poly (ADP-ribose) polymerase
Isotype Mouse IgG1, κ
描述
PARP（聚ADP核糖聚合酶）是一种113kD的核蛋白，可以作为同源或异源二聚体存在。这种蛋白质充当分子“缺口传感器”，在碱基切除修复、参与染色质结构和DNA代谢的受体蛋白的多（ADP-核糖基）化中发挥作用，并参与蛋白质修饰以增强或抑制转录。PARP被PARP2核糖基化，是细胞凋亡过程中胱天蛋白酶切割的靶点。PARP与至少含有XRCC1、PARP2、POLB和LIG3的碱基切除修复复合物中的蛋白质相互作用。此外，PARP与PARP2形成异二聚体，并与PARP3相互作用。5A5单克隆抗体识别人和小鼠PARP的N-末端区域，并已被证明可用于蛋白质印迹和免疫荧光染色。
PARP (Poly (ADP-ribose) polymerase) is a 113 kD nuclear protein that can exist as a homo- or hetero-dimer. This protein acts as a molecular "nick sensor" and functions in base excision repair, poly(ADP-ribosyl)ation of acceptor proteins involved in chromatin architecture and DNA metabolism and participates in protein modification to enhance or repress transcription. PARP is ribosylated by PARP2 and is a target for caspase cleavage during apoptosis. PARP interacts with proteins in the base excision repair complex containing at least XRCC1, PARP2, POLB and LIG3. In addition PARP forms heterodimers with PARP2, and interacts with PARP3. The 5A5 monoclonal antibody recognizes the N-terminal region of human and mouse PARP and has been shown to be useful for Western blotting and immunofluorescence staining.
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen
Recombinant (partial), N-terminal 2/3 sequence of PARP
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration 0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application ICC - Quality tested
IHC-P - Verified
Recommended Usage
Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, the suggested use is 2.5 - 5.0 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
Antigen Details
Structure PARP family, BRCT domain, homo- or hetero-dimer; 113 kD
Distribution Nuclear
Function
Molecular "nick sensor"; base excision repair, catalyzes poly(ADP-ribosyl)ation of acceptor proteins involved in chromatin architecture, DNA metabolism; protein modification may enhance or repress transcription
Interaction
Component of a base excision repair complex containing at least XRCC1, PARP2, POLB and LIG3. Heterodimerizes with PARP2, interacts with PARP3, modifies TATA-BP, YY1, Sp1, NF-B, p53 and others
Modification Ribosylation by PARP2
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, DNA Repair/Replication, Transcription Factors
Molecular Family Nuclear Markers
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BioLegend 614308 Alexa Fluor® 647 anti-PARP
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