BioLegend 316302 Purified anti

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BioLegend 316302 Purified anti-human β2-microglobulin
产品简介：
产品品牌：BioLegend
产品货号：316302
产品名称：BioLegend 316302 Purified anti-human β2-microglobulin
产品规格：100 µg

产品说明：
Clone  2M2 (See other available formats)
Regulatory Status  RUO
Other Names  β2M, β2-M, beta2-microglobulin b2-M, b2M
Isotype  Mouse IgG1, κ

描述
β2-微球蛋白（β2M）是一种12 kD非多态性Ig样蛋白。它是一种非膜锚定糖蛋白，与MHC I类分子的39-44 kD多态性重链非共价结合，形成HLA I类抗原复合物。与 HLA I 级相关，β2M 在所有白细胞、血小板、内皮细胞和上皮细胞上表达。β2M在控制MHC I类分子稳定性和促进抗原结合和将抗原呈递给CD8+ T细胞的CD3 / TCR复合物方面起着至关重要的作用。
β2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.

Product Details
Isotype Control  Purified Mouse IgG1, κ Isotype Ctrl
Verified Reactivity  Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus, Pig
Antibody Type  Monoclonal
Host Species  Mouse
Immunogen  Purified human β2-microglobulin
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration  0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application  FC - Quality tested
WB, ELISA - Reported in the literature, not verified in house

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes
Additional reported applications (for the relevant formats) include: Western blotting, and ELISA.

Antigen Details
Structure
Nonpolymorphic Ig like structure, noncovalently associated with heavy chain of MHC class I molecules, 12 kD

Distribution
Leukocytes, platelets, endothelial cells, epithelial cells
Function
Govern MHC class I molecule stability, promote MHC class I molecules binding and presenting peptide antigens to CD8+ T cells
Ligand/Receptor  CD3/TCR complex, CD8
Cell Type
Endothelial cells, Epithelial cells, Leukocytes, Platelets
Biology Area  Immunology
Molecular Family  MHC Antigens

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