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应用LC-MS技术，定量检测血液、尿液、唾液、泪液、动植物组织等生物样本中分子量小于1000道尔 顿的所有内源性代谢物。结合多元统计分析（如，主成分分析、偏最小二乘判别分析、正交偏最小二乘法判 别分析）及代谢相关网络分析，探讨发生紊乱的代谢途径与代谢机制。
产品优势：
检测覆盖全面：检测代谢物涵盖氨基酸代谢、糖代谢、核酸代谢、激素代谢、脂质代谢等常用代谢通路。数据库覆盖哺乳动物血浆700+/组织550+代谢物。
物质鉴定可靠：基于同位素内标、代谢物保留时间和超过80万个代谢物的二级谱库，确保代谢物的准确鉴定。客户还可选择进行差异最显著离子（未知代谢物）的额外鉴定。
数据定量精确：引入60+同位素内标，代谢物平均COV＜10%（提供QC样本质控结果图）
通路分析扩展：除了常规的KEGG、SMPDB数据库，还可扩展Reactome、Wikipathways数据库，深度挖掘数据信息。
产品优势：
检测覆盖全面：检测代谢物涵盖氨基酸代谢、糖代谢、核酸代谢、激素代谢、脂质代谢等常用代谢通路。数据库覆盖哺乳动物血浆700+/组织550+代谢物。
物质鉴定可靠：基于同位素内标、代谢物保留时间和超过80万个代谢物的二级谱库，确保代谢物的准确鉴定。客户还可选择进行差异最显著离子（未知代谢物）的额外鉴定。
数据定量精确：引入60+同位素内标，代谢物平均COV＜10%（提供QC样本质控结果图）
通路分析扩展：除了常规的KEGG、SMPDB数据库，还可扩展Reactome、Wikipathways数据库，深度挖掘数据信息。
- 通过正相色谱、反相色谱、HILIC亲水色谱对不同化合物进行色谱洗脱后，搭配 电喷雾离子源（ESI）进行质谱分析。
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文献和实验该产品被引用文献
发表文献：
1. Jing-gang Xia, Bowen Li, Hao Zhang, Qin-xue Li, Sin Man Lam, Chun-lin Yin*, He Tian* and Guanghou Shui*. Precise Metabolomics Defines Systemic Metabolic Dysregulation Distinct to Acute Myocardial Infarction Associated With Diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Apr;43(4):581-596. (IF: 8.7)
2. He Tian, Zhen Ni, Sin Man Lam, Wenxi Jiang, Fengjuan Li, Jie Du*, Yuan Wang*, Guanghou Shui*. Precise Metabolomics Reveals a Diversity of Aging-Associated Metabolic Features. Small Methods, 2022 Jul;6(7):e2200130. (IF: 12.4)
3. Xiupeng Chen, Jie Li, Zhongbao Gao, Yang Yang, Wenqing Kuang, Yue Dong, Gek Huey Chua, Xiahe Huang, Binhua Jiang, He Tian, Yingchun Wang, Xun Huang, Yan Li , Sin Man Lam*, Guanghou Shui*. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural–glial coupling in Drosophila. National Science Review, 2022 Jul 27;9(12):nwac148. (IF: 20.6)
4. Sha Huang, Yang Guo, Zhong Wu Li, Guanghou Shui, He Tian, Bo-Wen Li, Gaohaer Kadeerhan, Zhe-Xuan Li, Xue Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li. Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer. JAMA Network Open, 2021 Jun 1;4(6):e2114186. (IF: 13.8)
5. Long Shen, Penghui Hu, Yanan Zhang, Zemin Ji, Xiao Shan, Lina Ni, Na Ning, Jing Wang, He Tian, Guanghou Shui, Yukang Yuan, Guoli Li, Hui Zheng, Xiang-Ping Yang, Dandan Huang, Xiangling Feng, Mulin Jun Li, Zhe Liu, Ting Wang, Qiujing Yu*.Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation. Cell Metabolism. 2021 May 4; 33(5):971-987.e6. (IF: 29)
1. Jing-gang Xia, Bowen Li, Hao Zhang, Qin-xue Li, Sin Man Lam, Chun-lin Yin*, He Tian* and Guanghou Shui*. Precise Metabolomics Defines Systemic Metabolic Dysregulation Distinct to Acute Myocardial Infarction Associated With Diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Apr;43(4):581-596. (IF: 8.7)
2. He Tian, Zhen Ni, Sin Man Lam, Wenxi Jiang, Fengjuan Li, Jie Du*, Yuan Wang*, Guanghou Shui*. Precise Metabolomics Reveals a Diversity of Aging-Associated Metabolic Features. Small Methods, 2022 Jul;6(7):e2200130. (IF: 12.4)
3. Xiupeng Chen, Jie Li, Zhongbao Gao, Yang Yang, Wenqing Kuang, Yue Dong, Gek Huey Chua, Xiahe Huang, Binhua Jiang, He Tian, Yingchun Wang, Xun Huang, Yan Li , Sin Man Lam*, Guanghou Shui*. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural–glial coupling in Drosophila. National Science Review, 2022 Jul 27;9(12):nwac148. (IF: 20.6)
4. Sha Huang, Yang Guo, Zhong Wu Li, Guanghou Shui, He Tian, Bo-Wen Li, Gaohaer Kadeerhan, Zhe-Xuan Li, Xue Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li. Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer. JAMA Network Open, 2021 Jun 1;4(6):e2114186. (IF: 13.8)
5. Long Shen, Penghui Hu, Yanan Zhang, Zemin Ji, Xiao Shan, Lina Ni, Na Ning, Jing Wang, He Tian, Guanghou Shui, Yukang Yuan, Guoli Li, Hui Zheng, Xiang-Ping Yang, Dandan Huang, Xiangling Feng, Mulin Jun Li, Zhe Liu, Ting Wang, Qiujing Yu*.Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation. Cell Metabolism. 2021 May 4; 33(5):971-987.e6. (IF: 29)
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精确代谢组学
￥500 - 2000
