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Human Kallikrein 10 (诊断原料,肿瘤标志物)
Recombinant Human Kallikrein 10/KLK10
Catalog #: DC360 Derived From: Human Cells
Description:
Recombinant Human Kallikrein 10/KLK10 (C-6His) is produced by Mammalian expression system and the target gene encoding Ala31-Asn276 is expressed with a 6His tag at the C-terminus.
Accession: AAH02710.1
Names(Known as):Kallikrein-10; Normal Epithelial Cell-Specific 1; Protease Serine-Like 1; KLK10; NES1; PRSSL1
Quality Control:
Mol Mass: 27.98kDa AP Mol Mass: 34kDa, reducing conditions
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Formulation:
Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
Shipping:
The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography.
Immunoreactivity:
N.A.
Application:
Immunogen, calibrator or standard.
Background:
Kallikreins are a subgroup of Serine Proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
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文献和实验肿瘤基因P53抗体(P53-AB) 正常范围:肿瘤基因P53抗体阴性。 检查介绍:P53基因是研究得比较广泛深入的一个基因。P53抗体可用于各种肿瘤的早期诊断和肿瘤的筛选试验。 临床意义:在肿瘤血清中P53抗体呈阳性的患者中,其抗体出现早于临床症状的占10%~20%。常见于乳腺癌、肺癌、结肠癌、膀胱癌、前列腺癌及脑癌等。 神经元特异性烯醇化酶(NSE) 正常范围:放射
文献速递:全面液体分析循环肿瘤DNA和蛋白质生物标志物为评估预后带来新的可能
研究背景 肝细胞癌(HCC)被认为是中国癌症相关死亡率的第三大原因。尽管手术是治疗HCC的较佳选择,但由于缺乏早期症状,大多数患者在癌症晚期才被诊断出来,因此肿瘤复发的风险很高。识别可能复发的患者并给予对应的辅助治疗,仍然是一个临床难题。循环肿瘤DNA(ctDNA),也可称为肿瘤衍生的细胞游离DNA,包含有关肿瘤基因组图谱的全面信息,包括单核苷酸变异(SNVs)、拷贝数变异(CNVs)和表观遗传变异。将ctDNA与HCC中的传统血清蛋白生物标志物结合将为无创监测实时肿瘤进展提供新的可能。
等密切相关。膀胱癌时大量肿瘤细胞凋亡并将NMP22释放入尿,尿中NMP22可增高25 倍。以10kU/mL为临界值,对膀胱癌诊断的敏感度为70%,特异度78.5%。对浸润性膀胱癌诊断的敏感度为100% 。 17、α-L-岩藻糖苷酶(AFU) AFU是对原发性肝细胞性肝癌检测的又一敏感、特异的新标志物。原发性肝癌患者血清AFU活力显著高于其它各类疾患(包括良、恶性肿瘤)。血清AFU活性动态曲线对判断肝癌治疗效果、估计预后和预报复发有着极其重要的意义
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