Human Vitronectin (诊断原料,肿瘤标志物）

Recombinant Human Vitronectin 

 

Catalog #:  DC395        Derived From: Human Cells   

 

Description:

Recombinant Human Vitronectin/VTN (C-6His) is produced by Mammalian expression system and the target gene encoding Asp20-Leu478 is expressed with a 6His tag at the C-terminus.

Accession:  AAH05046.1

Names(Known as):Vitronectin; VN; S-Protein; Serum-Spreading Factor; V75; VTN

 

Quality Control:

Mol Mass:  53.35kDa               AP Mol Mass:  59kDa, reducing conditions

Purity:  Greater than 95% as determined by reducing SDS-PAGE.

 

Formulation:

Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

 

Shipping:

The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.

 

Storage:

Reconstituted protein solution should be stored at ≤ -20°C

 

Purification: 
Affinity purification chromatography

 

Immunoreactivity: 
N.A.

 

Application:
Immunogen, calibrator or standard

 

Background:

Human Vitronectin/VTN is a cell adhesion and spreading factor. It can be found in the blood and the extracellular matrix (ECM). Vitronectin interacts with glycosaminoglycans and proteoglycans. The multimeric Vitronectin can efficiently bind to and incorporate into the ECM; Vitronectin can support cell adhesion through binding to various integrins and other proteoglycans. Vitronectin can be recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecular. It can as a inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Vitronectin contains an endogenous cleavage site, plus cleavage sites for elastase, thrombin, and plasmin.

 

FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY