- 询价
- Cell Signaling Technology
- 2552
- USA
- 2025年08月09日
- W, IP
- Rabbit
- H,M,R
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- 详细信息
- 技术资料
- 抗体英文名：
p27 Kip1 Antibody
- 抗原：
synthetic peptide corresponding to the sequence of mouse p27
- 应用范围：
W, IP
- 宿主：
Rabbit
- 适应物种：
H,M,R
- 供应商：
CST
- 级别：
详见MSDS文件
- 库存：
大量
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M R | Endogenous | 27 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | p27 Kip1 Antibody detects endogenous levels of total p27 protein. The antibody may recognize p57 Kip2 |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of mouse p27. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from C6, NIH/3T3, HeLa and MCF-7 cells, using p27 Kip1 Antibody. |
| Background | p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by treatment with interleukin-2 or other mitogens; this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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