单克隆抗体特异性识别的野生型谷胱甘肽-S-转移酶进展
互联网
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Glutathione S-transferase omega 1 (GSTO-1) exists as both a wild-type (wt) and a mutant (mut) enzyme due to a polymorphism in a single amino acid Ala140Asp. (1) The role that this gene product plays in connection with a range of disease conditions has been investigated.(2,4) An antibody capable of specifically detecting wtGST would be of clinical significance to further elucidate the role that wtGST01 plays in disease states.
The aim of this work was to develop a highly specific monoclonal antibody, which will be used as a tool in the development of clinical research and clinical immunoassays.
