HSV Vectors for Gene Therapy
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A number of aspects of the natural biology of herpes simplex virus (HSV) make it an attractive candidate for a vector to express foreign genes within the nervous system. Some of the advantages of an HSV vector are
| 1 |
Establishment of a life-long latent infection within peripheral and central nervous system neurons (for a review, see ref,1 );
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| 2 |
Latent HSV genomes exist as multiple episomal copies/neuron and integration is not known to occur (2 ), and
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| 3. |
Nonreplicating HSV recombinants can establish a latent infection efficiently (3 )
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