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        帮忙看看我用ppxa0049设计的引物

        丁香园论坛

        4404
        上游5-TCCGTAAAGACCTCTATGCC,下游引物5-GCTCAGTAACAGTCCGCCTA,大鼠b-actin内对照.原始基因如下:
        1: NM_012580. Reports Rattus norvegicus...[gi:61098187] Links

        LOCUS NM_012580 1600 bp mRNA linear ROD 07-JUN-2005
        DEFINITION Rattus norvegicus heme oxygenase (decycling) 1 (Hmox1), mRNA.
        ACCESSION NM_012580
        VERSION NM_012580.2 GI:61098187
        KEYWORDS .
        SOURCE Rattus norvegicus (Norway rat)
        ORGANISM Rattus norvegicus
        Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
        Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
        Sciurognathi; Muridae; Murinae; Rattus.
        REFERENCE 1 (bases 1 to 1600)
        AUTHORS Di Filippo,C., Marfella,R., Cuzzocrea,S., Piegari,E.,
        Petronella,P., Giugliano,D., Rossi,F. and D'Amico,M.
        TITLE Hyperglycemia in streptozotocin-induced diabetic rat increases
        infarct size associated with low levels of myocardial HO-1 during
        ischemia/reperfusion
        JOURNAL Diabetes 54 (3), 803-810 (2005)
        PUBMED 15734859
        REMARK GeneRIF: This study investigated the role of heme oxygenase (HO)-1
        in the cardiac tissue injury of acute ischemia/reperfusion (I/R) in
        diabetic streptozotocin (STZ)-induced hyperglycemic rats.
        REFERENCE 2 (bases 1 to 1600)
        AUTHORS Munoz,A.M., Rey,P., Parga,J., Guerra,M.J. and
        Labandeira-Garcia,J.L.
        TITLE Glial overexpression of heme oxygenase-1: a histochemical marker
        for early stages of striatal damage
        JOURNAL J. Chem. Neuroanat. 29 (2), 113-126 (2005)
        PUBMED 15652698
        REMARK GeneRIF: The results indicate that determination of glial HO-1-ir
        is a useful histochemical marker for early stages of striatal
        damage.
        REFERENCE 3 (bases 1 to 1600)
        AUTHORS Liu,X.M., Peyton,K.J., Ensenat,D., Wang,H., Schafer,A.I., Alam,J.
        and Durante,W.
        TITLE Endoplasmic reticulum stress stimulates heme oxygenase-1 gene
        expression in vascular smooth muscle. Role in cell survival
        JOURNAL J. Biol. Chem. 280 (2), 872-877 (2005)
        PUBMED 15546873
        REMARK GeneRIF: capacity of endoplasmic reticulum stress to stimulate the
        HO-1/carbon monoxide system provides a novel mechanism by which
        this organelle regulates cell survival
        REFERENCE 4 (bases 1 to 1600)
        AUTHORS Salinas,M., Wang,J., Rosa de Sagarra,M., Martin,D., Rojo,A.I.,
        Martin-Perez,J., Ortiz de Montellano,P.R. and Cuadrado,A.
        TITLE Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and
        in vivo
        JOURNAL FEBS Lett. 578 (1-2), 90-94 (2004)
        PUBMED 15581622
        REMARK GeneRIF: Results provide the first evidence for a role of the
        survival kinase Akt in the regulation of heme oxygenase-1.
        REFERENCE 5 (bases 1 to 1600)
        AUTHORS Oermann,E., Bidmon,H.J., Witte,O.W. and Zilles,K.
        TITLE Effects of 1alpha,25 dihydroxyvitamin D3 on the expression of HO-1
        and GFAP in glial cells of the photothrombotically lesioned
        cerebral cortex
        JOURNAL J. Chem. Neuroanat. 28 (4), 225-238 (2004)
        PUBMED 15531134
        REMARK GeneRIF: Calcitriol increases expression in Rose Bengal-caused
        cerebral thrombosi.
        REFERENCE 6 (bases 1 to 1600)
        AUTHORS Yang,N.C., Lu,L.H., Kao,Y.H. and Chau,L.Y.
        TITLE Heme oxygenase-1 attenuates interleukin-1beta-induced nitric oxide
        synthase expression in vascular smooth muscle cells
        JOURNAL J. Biomed. Sci. 11 (6), 799-809 (2004)
        PUBMED 15591777
        REMARK GeneRIF: HO-1 attenuates IL-1beta-induced iNOS gene expression in
        vascular smooth muscle cells
        REFERENCE 7 (bases 1 to 1600)
        AUTHORS Hartsfield,C.L., McMurtry,I.F., Ivy,D.D., Morris,K.G., Vidmar,S.,
        Rodman,D.M. and Fagan,K.A.
        TITLE Cardioprotective and vasomotor effects of HO activity during acute
        and chronic hypoxia
        JOURNAL Am. J. Physiol. Heart Circ. Physiol. 287 (5), H2009-H2015 (2004)
        PUBMED 15217799
        REMARK GeneRIF: Inhibition of HO and carbon monoxide (CO) production does
        not exacerbate pulmonary hypertension. Rather, HO and CO may be
        involved in mediating pulmonary and systemic vasoreactivity to
        acute hypoxia and hypoxia-induced right ventricular function.
        REFERENCE 8 (bases 1 to 1600)
        AUTHORS Akins,R. Jr., McLaughlin,T., Boyce,R., Gilmour,L. and Gratton,K.
        TITLE Exogenous metalloporphyrins alter the organization and function of
        cultured neonatal rat heart cells via modulation of heme oxygenase
        activity
        JOURNAL J. Cell. Physiol. 201 (1), 26-34 (2004)
        PUBMED 15281086
        REMARK GeneRIF: Treatment of heart cells with heme metabolically inhibited
        increased HO activity
        REFERENCE 9 (bases 1 to 1600)
        AUTHORS Choi,B.M., Kim,Y.M., Jeong,Y.R., Pae,H.O., Song,C.E., Park,J.E.,
        Ahn,Y.K. and Chung,H.T.
        TITLE Induction of heme oxygenase-1 is involved in anti-proliferative
        effects of paclitaxel on rat vascular smooth muscle cells
        JOURNAL Biochem. Biophys. Res. Commun. 321 (1), 132-137 (2004)
        PUBMED 15358225
        REMARK GeneRIF: Paclitaxel induces the expression of HO-1 via the JN
        kinase pathway in vascular smooth muscle and that HO-1 expression
        might be responsible for the anti-proliferative effect of
        paclitaxel on VSMC.
        REFERENCE 10 (bases 1 to 1600)
        AUTHORS Taille,C., El-Benna,J., Lanone,S., Dang,M.C., Ogier-Denis,E.,
        Aubier,M. and Boczkowski,J.
        TITLE Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by
        down-regulating cytochrome b558 expression via the reduction of
        heme availability
        JOURNAL J. Biol. Chem. 279 (27), 28681-28688 (2004)
        PUBMED 15123630
        REMARK GeneRIF: heme oxygenase-1 inhibits NAD(P)H oxidase activity by
        down-regulating cytochrome b558 expression via the reduction of
        heme availability
        REFERENCE 11 (bases 1 to 1600)
        AUTHORS Kim,H.P., Wang,X., Galbiati,F., Ryter,S.W. and Choi,A.M.
        TITLE Caveolae compartmentalization of heme oxygenase-1 in endothelial
        cells
        JOURNAL FASEB J. 18 (10), 1080-1089 (2004)
        PUBMED 15226268
        REMARK GeneRIF: HO-1 interacts with caveolin-1 (inhibitory) and localizes
        in part to specialized plasma membrane caveolae in rat pulmonary
        artery endothelial cells.
        REFERENCE 12 (bases 1 to 1600)
        AUTHORS Huang,X.L., Ling,Y.L., Ling,Y.Q., Zhou,J.L., Liu,Y. and Wang,Q.H.
        TITLE Heme oxygenase-1 in cholecystokinin-octapeptipe attenuated injury
        of pulmonary artery smooth muscle cells induced by
        lipopolysaccharide and its signal transduction mechanism
        JOURNAL World J. Gastroenterol. 10 (12), 1789-1794 (2004)
        PUBMED 15188507
        REMARK GeneRIF: HO-1 may be a key factor in CCK-8 attenuated injuries of
        pulmonary artery smooth muscle cells induced by lipopolysaccharides
        REFERENCE 13 (bases 1 to 1600)
        AUTHORS Johnson,W.T. and DeMars,L.C.
        TITLE Increased heme oxygenase-1 expression during copper deficiency in
        rats results from increased mitochondrial generation of hydrogen
        peroxide
        JOURNAL J. Nutr. 134 (6), 1328-1333 (2004)
        PUBMED 15173392
        REMARK GeneRIF: Increased mitochondrial H(2)O(2) production resulting from
        inhibition of respiratory complex activities contributes to
        induction of HO-1 in liver and heart during copper deficiency.
        REFERENCE 14 (bases 1 to 1600)
        AUTHORS Yang,Z.F., Tsui,T.Y., Ho,D.W., Tang,T.C. and Fan,S.T.
        TITLE Heme oxygenase-1 potentiates the survival of small-for-size liver
        graft
        JOURNAL Liver Transpl. 10 (6), 784-793 (2004)
        PUBMED 15162474
        REMARK GeneRIF: Beneficial effects of HO-1 on allograft survival. Ability
        of small-for-size grafts in induction of HO-1 expression might
        facilitate their own survival in liver transplantation.
        REFERENCE 15 (bases 1 to 1600)
        AUTHORS Takeda,K., Lin,J., Okubo,S., Akazawa-Kudoh,S., Kajinami,K.,
        Kanemitsu,S., Tsugawa,H., Kanda,T., Matsui,S. and Takekoshi,N.
        TITLE Transient glucose deprivation causes upregulation of heme
        oxygenase-1 and cyclooxygenase-2 expression in cardiac fibroblasts
        JOURNAL J. Mol. Cell. Cardiol. 36 (6), 821-830 (2004)
        PUBMED 15158123
        REMARK GeneRIF: briefly removing glucose from cultured cardiac fibroblasts
        induces COX-2 and HO-1 expression via generation of ROS and p38
        MAPK phosphorylation
        REFERENCE 16 (bases 1 to 1600)
        AUTHORS Lin,H.C., Cheng,T.H., Chen,Y.C. and Juan,S.H.
        TITLE Mechanism of heme oxygenase-1 gene induction by quercetin in rat
        aortic smooth muscle cells
        JOURNAL Pharmacology 71 (2), 107-112 (2004)
        PUBMED 15118350
        REMARK GeneRIF: HO-1 induction is beneficial for protecting blood vessels.
        that quercetin, a common polyphenolic compound in foods of plant
        origin, induces HO-1 expression in RAW264.7 cells.
        REFERENCE 17 (bases 1 to 1600)
        AUTHORS Attuwaybi,B.O., Kozar,R.A., Moore-Olufemi,S.D., Sato,N.,
        Hassoun,H.T., Weisbrodt,N.W. and Moore,F.A.
        TITLE Heme oxygenase-1 induction by hemin protects against gut
        ischemia/reperfusion injury
        JOURNAL J. Surg. Res. 118 (1), 53-57 (2004)
        PUBMED 15093717
        REMARK GeneRIF: HO-1 plays an important role in protecting the gut against
        I/R-induced injury.
        REFERENCE 18 (bases 1 to 1600)
        AUTHORS Johnson,F.K., Durante,W., Peyton,K.J. and Johnson,R.A.
        TITLE Heme oxygenase-mediated endothelial dysfunction in DOCA-salt, but
        not in spontaneously hypertensive, rat arterioles
        JOURNAL Am. J. Physiol. Heart Circ. Physiol. 286 (5), H1681-H1687 (2004)
        PUBMED 14693679
        REMARK GeneRIF: Elevated HO-1 levels and activity, not resulting from
        hypertension per se, contribute to endothelial dysfunction in DOCA
        rats.
        REFERENCE 19 (bases 1 to 1600)
        AUTHORS Chen,Y.C., Gines,P., Yang,J., Summer,S.N., Falk,S., Russell,N.S.
        and Schrier,R.W.
        TITLE Increased vascular heme oxygenase-1 expression contributes to
        arterial vasodilation in experimental cirrhosis in rats
        JOURNAL Hepatology 39 (4), 1075-1087 (2004)
        PUBMED 15057912
        REMARK GeneRIF: increased expression of HO-1 was found in aorta and
        mesenteric arteries of bile duct ligation rats in a close
        chronologic relationship with the progression from acute
        cholestatic liver injury to fully developed cirrhosis with arterial
        vasodilation
        REFERENCE 20 (bases 1 to 1600)
        AUTHORS Komatsu,D.E. and Hadjiargyrou,M.
        TITLE Activation of the transcription factor HIF-1 and its target genes,
        VEGF, HO-1, iNOS, during fracture repair
        JOURNAL Bone 34 (4), 680-688 (2004)
        PUBMED 15050899
        REMARK GeneRIF: expression pattern of HIF-1alpha and selected HIF-1 target
        genes using a rat femoral fracture model
        REFERENCE 21 (bases 1 to 1600)
        AUTHORS Li Volti,G., Ientile,R., Abraham,N.G., Vanella,A., Cannavo,G.,
        Mazza,F., Curro,M., Raciti,G., Avola,R. and Campisi,A.
        TITLE Immunocytochemical localization and expression of heme oxygenase-1
        in primary astroglial cell cultures during differentiation: effect
        of glutamate
        JOURNAL Biochem. Biophys. Res. Commun. 315 (2), 517-524 (2004)
        PUBMED 14766239
        REMARK GeneRIF: HO-1 protein expression and localization in primary
        cultured astroglial cells may be part of the underlying mechanisms
        involved in brain development as well as in neurodegenerative
        disease
        REFERENCE 22 (bases 1 to 1600)
        AUTHORS Quan,S., Kaminski,P.M., Yang,L., Morita,T., Inaba,M., Ikehara,S.,
        Goodman,A.I., Wolin,M.S. and Abraham,N.G.
        TITLE Heme oxygenase-1 prevents superoxide anion-associated endothelial
        cell sloughing in diabetic rats
        JOURNAL Biochem. Biophys. Res. Commun. 315 (2), 509-516 (2004)
        PUBMED 14766238
        REMARK GeneRIF: HO-1 in diabetic rats regulates levels of serum bilirubin,
        O~undefined-)(2) production, and endothelial cell sloughing
        REFERENCE 23 (bases 1 to 1600)
        AUTHORS Li,Q.F. and Dai,A.G.
        TITLE Hypoxia inducible factor-1 alpha correlates the expression of heme
        oxygenase 1 gene in pulmonary arteries of rat with hypoxia-induced
        pulmonary hypertension
        JOURNAL Acta Biochim. Biophys. Sin. (Shanghai) 36 (2), 133-140 (2004)
        PUBMED 14970910
        REMARK GeneRIF: HIF-1alpha and HO-1 are involved in the pathogenesis of
        hypoxia-induced pulmonary hypertension in rat
        REFERENCE 24 (bases 1 to 1600)
        AUTHORS Oztezcan,S., Kirgiz,B., Unlucerci,Y., Dogru-Abbasoglu,S., Bilge,H.,
        Uysal,M. and Aykac-Toker,G.
        TITLE Heme oxygenase induction protects liver against oxidative stress in
        x-irradiated aged rats
        JOURNAL Biogerontology 5 (2), 99-105 (2004)
        PUBMED 15105584
        REMARK GeneRIF: These results suggest that oxidative stress produced in
        irradiated rats may be compensated by heme oxygenase-1 induction.
        REFERENCE 25 (bases 1 to 1600)
        AUTHORS Weng,Y.H., Yang,G., Weiss,S. and Dennery,P.A.
        TITLE Interaction between heme oxygenase-1 and -2 proteins
        JOURNAL J. Biol. Chem. 278 (51), 50999-51005 (2003)
        PUBMED 14514669
        REMARK GeneRIF: demonstrated an interaction between Hmox1 and Hmox2 at
        amino acids 0-45 of Hmox2 and amino acids 58-80 of Hmox1,
        corresponding to a highly conserved, hydrophilic, and exposed
        region of the protein
        REFERENCE 26 (bases 1 to 1600)
        AUTHORS Farhangkhoee,H., Khan,Z.A., Mukherjee,S., Cukiernik,M.,
        Barbin,Y.P., Karmazyn,M. and Chakrabarti,S.
        TITLE Heme oxygenase in diabetes-induced oxidative stress in the heart
        JOURNAL J. Mol. Cell. Cardiol. 35 (12), 1439-1448 (2003)
        PUBMED 14654370
        REMARK GeneRIF: Ho-1 level increased in cardiac myocytes one-month after
        diabetes mellitus.
        REFERENCE 27 (bases 1 to 1600)
        AUTHORS Zhang,J., Ling,Y., Luo,B., Tang,L., Ryter,S.W., Stockard,C.R.,
        Grizzle,W.E. and Fallon,M.B.
        TITLE Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase
        alterations in experimental hepatopulmonary syndrome
        JOURNAL Gastroenterology 125 (5), 1441-1451 (2003)
        PUBMED 14598260
        REMARK GeneRIF: The heme oxygenase-1/carbon monoxide system is an
        important contributor to the progression of experimental
        hepatopulmonary syndrome in addition to alterations in the
        endothelial nitric oxide synthase/nitric oxide pathway.
        REFERENCE 28 (bases 1 to 1600)
        AUTHORS Attuwaybi,B.O., Hassoun,H.T., Zou,L., Kozar,R.A., Kone,B.C.,
        Weisbrodt,N.W. and Moore,F.A.
        TITLE Hypothermia protects against gut ischemia/reperfusion-induced
        impaired intestinal transit by inducing heme oxygenase-1
        JOURNAL J. Surg. Res. 115 (1), 48-55 (2003)
        PUBMED 14572772
        REMARK GeneRIF: intraischemic regional hypothermia protects against
        histological injury and impaired intestinal transit caused by
        severe gut ischemia-reperfusion injury in part due to heme
        oxygenase-1 expression
        REFERENCE 29 (bases 1 to 1600)
        AUTHORS Patel,J., Manjappa,N., Bhat,R., Mehrotra,P., Bhaskaran,M. and
        Singhal,P.C.
        TITLE Role of oxidative stress and heme oxygenase activity in
        morphine-induced glomerular epithelial cell growth
        JOURNAL Am. J. Physiol. Renal Physiol. 285 (5), F861-F869 (2003)
        PUBMED 12812915
        REMARK GeneRIF: Heme oxygenase activity is directly related to glomerular
        epithelial cell(GEC) apoptosis and inversely related to GEC
        proliferation. Morphine had dose-related effects on HO activity. HO
        activity may be modifying morphine-induced GEC growth.
        REFERENCE 30 (bases 1 to 1600)
        AUTHORS Liu,H., Nowak,R., Chao,W. and Bloch,K.D.
        TITLE Nerve growth factor induces anti-apoptotic heme oxygenase-1 in rat
        pheochromocytoma PC12 cells
        JOURNAL J. Neurochem. 86 (6), 1553-1563 (2003)
        PUBMED 12950464
        REMARK GeneRIF: NGF enhances HO-1 gene transcription via MEK activation
        and that the induction of HO-1 plays an important role in the
        antioxidative and antiapoptotic effects of NGF in serum-deprived
        PC12 cells
        REFERENCE 31 (bases 1 to 1600)
        AUTHORS Ke,B., Shen,X.D., Lassman,C.R., Gao,F., Busuttil,R.W. and
        Kupiec-Weglinski,J.W.
        TITLE Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold
        ischemia/reperfusion injury are heme oxygenase-1 dependent
        JOURNAL Am J Transplant 3 (9), 1076-1082 (2003)
        PUBMED 12919086
        REMARK GeneRIF: Inhibition of HO-1 with tin protoporphyrin reversed
        cytoprotective/antiapoptotic effects of IL-13 in liver
        transplantation.
        REFERENCE 32 (bases 1 to 1600)
        AUTHORS Jonas,J.C., Guiot,Y., Rahier,J. and Henquin,J.C.
        TITLE Haeme-oxygenase 1 expression in rat pancreatic beta cells is
        stimulated by supraphysiological glucose concentrations and by
        cyclic AMP
        JOURNAL Diabetologia 46 (9), 1234-1244 (2003)
        PUBMED 12898011
        REMARK GeneRIF: High glucose concentrations and cyclic AMP increase
        beta-cell HO1 protein expression/
        REFERENCE 33 (bases 1 to 1600)
        AUTHORS Wang,T., Sterling,H., Shao,W.A., Yan,Q., Bailey,M.A., Giebisch,G.
        and Wang,W.H.
        TITLE Inhibition of heme oxygenase decreases sodium and fluid absorption
        in the loop of Henle
        JOURNAL Am. J. Physiol. Renal Physiol. 285 (3), F484-F490 (2003)
        PUBMED 12890663
        REMARK GeneRIF: high-potassium intake increases HO-2 expression in the
        kidney and that HO-dependent metabolites of heme, presumably CO,
        play a significant role in the regulation of Na+ transport in the
        loop of Henle
        REFERENCE 34 (bases 1 to 1600)
        AUTHORS Sugishima,M., Sakamoto,H., Higashimoto,Y., Noguchi,M. and
        Fukuyama,K.
        TITLE Crystal structure of rat heme oxygenase-1 in complex with
        biliverdin-iron chelate. Conformational change of the distal helix
        during the heme cleavage reaction
        JOURNAL J. Biol. Chem. 278 (34), 32352-32358 (2003)
        PUBMED 12794075
        REMARK GeneRIF: crystal structure in complex with biliverdin-iron chelate
        REFERENCE 35 (bases 1 to 1600)
        AUTHORS Gong,P., Cederbaum,A.I. and Nieto,N.
        TITLE Increased expression of cytochrome P450 2E1 induces heme
        oxygenase-1 through ERK MAPK pathway
        JOURNAL J. Biol. Chem. 278 (32), 29693-29700 (2003)
        PUBMED 12777398
        REMARK GeneRIF: heme oxygenase 1 is induced by P4502E1 through ERK MAPK
        pathway
        REFERENCE 36 (bases 1 to 1600)
        AUTHORS Araujo,J.A., Meng,L., Tward,A.D., Hancock,W.W., Zhai,Y., Lee,A.,
        Ishikawa,K., Iyer,S., Buelow,R., Busuttil,R.W., Shih,D.M.,
        Lusis,A.J. and Kupiec-Weglinski,J.W.
        TITLE Systemic rather than local heme oxygenase-1 overexpression improves
        cardiac allograft outcomes in a new transgenic mouse
        JOURNAL J. Immunol. 171 (3), 1572-1580 (2003)
        PUBMED 12874251
        REMARK GeneRIF: Hearts transplanted into heme oxygenase-1 transgenic mice
        recipients show decreased CD4+ lymphocyte infiltration and
        diminished immune activation, as judged by CD25 expression.
        REFERENCE 37 (bases 1 to 1600)
        AUTHORS Guo,J.S., Cho,C.H., Wang,W.P., Shen,X.Z., Cheng,C.L. and Koo,M.W.
        TITLE Expression and activities of three inducible enzymes in the healing
        of gastric ulcers in rats
        JOURNAL World J. Gastroenterol. 9 (8), 1767-1771 (2003)
        PUBMED 12918117
        REMARK GeneRIF: xpression and activities of inducible NOS, HO-1 and COX-2
        are found to be correlated to different stages of gastric
        ulceration. Inducible NOS may contribute to ulcer formation while
        HO-1 and COX-2 may promote ulcer healing.
        REFERENCE 38 (bases 1 to 1600)
        AUTHORS Bechtold,D.A. and Brown,I.R.
        TITLE Induction of Hsp27 and Hsp32 stress proteins and vimentin in glial
        cells of the rat hippocampus following hyperthermia
        JOURNAL Neurochem. Res. 28 (8), 1163-1173 (2003)
        PUBMED 12834255
        REMARK GeneRIF: induction in glial cells of hippocampus following
        hyperthermia (Hsp32).
        REFERENCE 39 (bases 1 to 1600)
        AUTHORS Kreiser,D., Kelly,D.K., Seidman,D.S., Stevenson,D.K., Baum,M. and
        Dennery,P.A.
        TITLE Gestational pattern of heme oxygenase expression in the rat
        JOURNAL Pediatr. Res. 54 (2), 172-178 (2003)
        PUBMED 12736392
        REMARK GeneRIF: In the uterus, HO-1 and HO-2 protein and total mRNA levels
        peaked on d 16 of pregnancy, whereas, in the placenta, HO-1 and
        HO-2 protein levels peaked on d 19.
        REFERENCE 40 (bases 1 to 1600)
        AUTHORS Wagener,F.A., van Beurden,H.E., von den Hoff,J.W., Adema,G.J. and
        Figdor,C.G.
        TITLE The heme-heme oxygenase system: a molecular switch in wound healing
        JOURNAL Blood 102 (2), 521-528 (2003)
        PUBMED 12649161
        REMARK GeneRIF: HO-1 is made in mucosal & skin epithelia of animals
        without wounds. On inflammation, expression increased, particularly
        in infiltrating cells during resolution. HO-1 antagonizes
        inflammation by attenuating adhesive interactions & cellular
        infiltration.
        REFERENCE 41 (bases 1 to 1600)
        AUTHORS Noriega,G.O., Tomaro,M.L. and del Batlle,A.M.
        TITLE Bilirubin is highly effective in preventing in vivo
        delta-aminolevulinic acid-induced oxidative cell damage
        JOURNAL Biochim. Biophys. Acta 1638 (2), 173-178 (2003)
        PUBMED 12853123
        REFERENCE 42 (bases 1 to 1600)
        AUTHORS Tsui,T.Y., Wu,X., Lau,C.K., Ho,D.W., Xu,T., Siu,Y.T. and Fan,S.T.
        TITLE Prevention of chronic deterioration of heart allograft by
        recombinant adeno-associated virus-mediated heme oxygenase-1 gene
        transfer
        JOURNAL Circulation 107 (20), 2623-2629 (2003)
        PUBMED 12732603
        REMARK GeneRIF: Recombinant adeno-associated virus-mediated heme
        oxygenase-1 gene transfer represents a novel therapeutic approach
        to prevent chronic allograft deterioration in clinical heart
        transplantation
        REFERENCE 43 (bases 1 to 1600)
        AUTHORS Kietzmann,T., Samoylenko,A. and Immenschuh,S.
        TITLE Transcriptional regulation of heme oxygenase-1 gene expression by
        MAP kinases of the JNK and p38 pathways in primary cultures of rat
        hepatocytes
        JOURNAL J. Biol. Chem. 278 (20), 17927-17936 (2003)
        PUBMED 12637567
        REMARK GeneRIF: the HO-1 CRE/AP-1 element mediates HO-1 gene induction via
        activation of JNK/c-Jun whereas p38 isoforms act through a
        different mechanism via the E-box
        REFERENCE 44 (bases 1 to 1600)
        AUTHORS Watanabe,T., Hasegawa,G., Yamamoto,T., Hatakeyama,K., Suematsu,M.
        and Naito,M.
        TITLE Expression of heme oxygenase-1 in rat ontogeny
        JOURNAL Arch. Histol. Cytol. 66 (2), 155-162 (2003)
        PUBMED 12846555
        REMARK GeneRIF: Hmox1 expression was studied in rat ontogeny.
        REFERENCE 45 (bases 1 to 1600)
        AUTHORS Masini,E., Vannacci,A., Marzocca,C., Pierpaoli,S., Giannini,L.,
        Fantappie,O., Mazzanti,R. and Mannaioni,P.F.
        TITLE Heme oxygenase-1 and the ischemia-reperfusion injury in the rat
        heart
        JOURNAL Exp. Biol. Med. (Maywood) 228 (5), 546-549 (2003)
        PUBMED 12709584
        REMARK GeneRIF: Data show that induction of heme oxygenase-1 by hemin
        significantly decreased infarct size, incidence of reperfusion
        arrhythmias, malondialdehyde generation, and calcium overload
        induced by focal ischemia-reperfusion in the rat heart.
        REFERENCE 46 (bases 1 to 1600)
        AUTHORS Mingone,C.J., Gupte,S.A., Quan,S., Abraham,N.G. and Wolin,M.S.
        TITLE Influence of heme and heme oxygenase-1 transfection of pulmonary
        microvascular endothelium on oxidant generation and cGMP
        JOURNAL Exp. Biol. Med. (Maywood) 228 (5), 535-539 (2003)
        PUBMED 12709582
        REMARK GeneRIF: Data suggest that heme and heme oxygenase-1 regulate
        soluble guanylate cyclase through mechanisms involving nitric oxide
        and carbon monoxide.
        REFERENCE 47 (bases 1 to 1600)
        AUTHORS Colombrita,C., Calabrese,V., Stella,A.M., Mattei,F., Alkon,D.L. and
        Scapagnini,G.
        TITLE Regional rat brain distribution of heme oxygenase-1 and manganese
        superoxide dismutase mRNA: relevance of redox homeostasis in the
        aging processes
        JOURNAL Exp. Biol. Med. (Maywood) 228 (5), 517-524 (2003)
        PUBMED 12709579
        REMARK GeneRIF: Results describe age-dependent differences in heme
        oxygenase-1 and manganese superoxide dismutase-2 expression in rat
        brain.
        REFERENCE 48 (bases 1 to 1600)
        AUTHORS Mostert,V., Hill,K.E., Ferris,C.D. and Burk,R.F.
        TITLE Selective induction of liver parenchymal cell heme oxygenase-1 in
        selenium-deficient rats
        JOURNAL Biol. Chem. 384 (4), 681-687 (2003)
        PUBMED 12751798
        REMARK GeneRIF: selenium deficiency affects hepatic antioxidant
        selenoproteins, resulting in an up-regulation of heme oxygenase 1
        REFERENCE 49 (bases 1 to 1600)
        AUTHORS Alam,J., Killeen,E., Gong,P., Naquin,R., Hu,B., Stewart,D.,
        Ingelfinger,J.R. and Nath,K.A.
        TITLE Heme activates the heme oxygenase-1 gene in renal epithelial cells
        by stabilizing Nrf2
        JOURNAL Am. J. Physiol. Renal Physiol. 284 (4), F743-F752 (2003)
        PUBMED 12453873
        REMARK GeneRIF: Expression of HO-1 is activated by heme in immortalized
        rat proximal tubular epithelial cells
        REFERENCE 50 (bases 1 to 1600)
        AUTHORS Kanakiriya,S.K., Croatt,A.J., Haggard,J.J., Ingelfinger,J.R.,
        Tang,S.S., Alam,J. and Nath,K.A.
        TITLE Heme: a novel inducer of MCP-1 through HO-dependent and
        HO-independent mechanisms
        JOURNAL Am. J. Physiol. Renal Physiol. 284 (3), F546-F554 (2003)
        PUBMED 12556365
        REMARK GeneRIF: Hemin elicited a dose- and time-dependent induction of
        HO-1 and MCP-1 mRNA in rat proximal tubular epithelial cells
        REFERENCE 51 (bases 1 to 1600)
        AUTHORS Suzuki,M., Iso-o,N., Takundefined*a~ES.~E_Tsukamoto~EK.~E_Mori~EI.~E_Sato~ET.~E~Kbr_~H~M~2~1Ohno~EM.~E_Nagai~ER._and_Ishizaka~EN.~Kbr_~H~M~2~1TITLE_Facilitated_angiogenesis_induced_by_heme_oxygenase~F1_gene_transfer~Kbr_~H~M~2~1in_a_rat_model_of_hindlimb_ischemia~Kbr_~H~M~2~1JOURNAL_Biochem._Biophys._Res._Commun._302_~A1~B~E_138~F143_~A2003~B~Kbr_~H~M~2~1PUBMED_12593860~Kbr_~H~M~2~1REMARK_GeneRIF~I_role_in_facilitating_angiogenesis_in_model_of_hindlimb~Kbr_~H~M~2~1ischemia~Kbr_~H~M~2~1REFERENCE_52_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Johnson~EF.K.~E_Durante~EW.~E_Peyton~EK.J._and_Johnson~ER.A.~Kbr_~H~M~2~1TITLE_Heme_oxygenase_inhibitor_restores_arteriolar_nitric_oxide_function~Kbr_~H~M~2~1in_dahl_rats~Kbr_~H~M~2~1JOURNAL_Hypertension_41_~A1~B~E_149~F155_~A2003~B~Kbr_~H~M~2~1PUBMED_12511545~Kbr_~H~M~2~1REFERENCE_53_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Kukoba~ET.V.~E_Moibenko~EO.O._and_Kotsioruba~EA.V.~Kbr_~H~M~2~1TITLE_~PCardioprotective_effect_of_heme_oxygenase~F1_induction_by_hemin_on~Kbr_~H~M~2~1the_isolated_rat_heart_during_ischemia~F~Freperfusion~Q~Kbr_~H~M~2~1JOURNAL_Fiziol_Zh_49_~A6~B~E_14~F21_~A2003~B~Kbr_~H~M~2~1PUBMED_14965033~Kbr_~H~M~2~1REMARK_GeneRIF~I_HO~F1_confers_cardiprotection_to_the_isolated_rat_heart~Kbr_~H~M~2~1during_ischemia~Freperfusion.~Kbr_~H~M~2~1REFERENCE_54_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Warskulat~EU.~E_Gorg~EB.~E_Bidmon~EH.J.~E_Muller~EH.W.~E_Schliess~EF._and~Kbr_~H~M~2~1Haussinger~ED.~Kbr_~H~M~2~1TITLE_Ammonia~Finduced_heme_oxygenase~F1_expression_in_cultured_rat~Kbr_~H~M~2~1astrocytes_and_rat_brain_in_vivo~Kbr_~H~M~2~1JOURNAL_Glia_40_~A3~B~E_324~F336_~A2002~B~Kbr_~H~M~2~1PUBMED_12420312~Kbr_~H~M~2~1REMARK_GeneRIF~I_HO~F1_mRNA_levels_were_upregulated_by_ammonia_after_24_h~Kbr_~H~M~2~1and_protein_expression_after_72_h_in_astrocytes._These_effects_on~Kbr_~H~M~2~1HO~F1_are_probably_triggered_by_ammonia~Finduced_glutamine_synthesis~Kbr_~H~M~2~1or_by_astrocyte_swelling.~Kbr_~H~M~2~1REFERENCE_55_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Sugishima~EM.~E_Sakamoto~EH.~E_Higashimoto~EY.~E_Omata~EY.~E_Hayashi~ES.~E~Kbr_~H~M~2~1Noguchi~EM._and_Fukuyama~EK.~Kbr_~H~M~2~1TITLE_Crystal_structure_of_rat_heme_oxygenase~F1_in_complex_with_heme~Kbr_~H~M~2~1bound_to_azide._Implication_for_regiospecific_hydroxylation_of_heme~Kbr_~H~M~2~1at_the_alpha~Fmeso_carbon~Kbr_~H~M~2~1JOURNAL_J._Biol._Chem._277_~A47~B~E_45086~F45090_~A2002~B~Kbr_~H~M~2~1PUBMED_12235152~Kbr_~H~M~2~1REMARK_GeneRIF~I_Results_describe_the_crystal_structure_of_rat_heme~Kbr_~H~M~2~1oxygenase_1_~AHO~F1~B_in_complex_with_heme_and_azide_~AHO~Fheme~FN~A3~B~A~F~B~B~Kbr_~H~M~2~1at_1.9~FA_resolution.~Kbr_~H~M~2~1REFERENCE_56_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Miyazono~EM.~E_Garat~EC.~E_Morris~EK.G._Jr._and_Carter~EE.P.~Kbr_~H~M~2~1TITLE_Decreased_renal_heme_oxygenase~F1_expression_contributes_to~Kbr_~H~M~2~1decreased_renal_function_during_cirrhosis~Kbr_~H~M~2~1JOURNAL_Am._J._Physiol._Renal_Physiol._283_~A5~B~E_F1123~FF1131_~A2002~B~Kbr_~H~M~2~1PUBMED_12372789~Kbr_~H~M~2~1REMARK_GeneRIF~I_decreased_renal_HO~F1_expression_contributes_to~Kbr_~H~M~2~1deteriorated_renal_function_and_hemodynamics_during_cirrhosis.~Kbr_~H~M~2~1REFERENCE_57_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Naughton~EP.~E_Foresti~ER.~E_Bains~ES.K.~E_Hoque~EM.~E_Green~EC.J._and~Kbr_~H~M~2~1Motterlini~ER.~Kbr_~H~M~2~1TITLE_Induction_of_heme_oxygenase_1_by_nitrosative_stress._A_role_for~Kbr_~H~M~2~1nitroxyl_anion~Kbr_~H~M~2~1JOURNAL_J._Biol._Chem._277_~A43~B~E_40666~F40674_~A2002~B~Kbr_~H~M~2~1PUBMED_12194971~Kbr_~H~M~2~1REMARK_GeneRIF~I_role_of_nitroxyl_anion_in_inducing_heme_oxygenase_1~Kbr_~H~M~2~1REFERENCE_58_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Ke~EB.~E_Shen~EX.D.~E_Zhai~EY.~E_Gao~EF.~E_Busuttil~ER.W.~E_Volk~EH.D._and~Kbr_~H~M~2~1Kupiec~FWeglinski~EJ.W.~Kbr_~H~M~2~1TITLE_Heme_oxygenase_1_mediates_the_immunomodulatory_and_antiapoptotic~Kbr_~H~M~2~1effects_of_interleukin_13_gene_therapy_in_vivo_and_in_vitro~Kbr_~H~M~2~1JOURNAL_Hum._Gene_Ther._13_~A15~B~E_1845~F1857_~A2002~B~Kbr_~H~M~2~1PUBMED_12396617~Kbr_~H~M~2~1REMARK_GeneRIF~I_Heme_oxygenase_1_mediates_the_immunomodulatory_and~Kbr_~H~M~2~1antiapoptotic_effects_of_interleukin_13_gene_therapy_in_vivo_in~Kbr_~H~M~2~1rats_and_in_vitro_in_human_cells.~Kbr_~H~M~2~1REFERENCE_59_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Lakkisto~EP.~E_Palojoki~EE.~E_Backlund~ET.~E_Saraste~EA.~E_Tikkanen~EI.~E~Kbr_~H~M~2~1Voipio~FPulkki~EL.M._and_Pulkki~EK.~Kbr_~H~M~2~1TITLE_Expression_of_heme_oxygenase~F1_in_response_to_myocardial_infarction~Kbr_~H~M~2~1in_rats~Kbr_~H~M~2~1JOURNAL_J._Mol._Cell._Cardiol._34_~A10~B~E_1357~F1365_~A2002~B~Kbr_~H~M~2~1PUBMED_12392996~Kbr_~H~M~2~1REMARK_GeneRIF~I_expression_and_localization_of_HO~F1_in_a_rat_experimental~Kbr_~H~M~2~1myocardial_infarction_model~Kbr_~H~M~2~1REFERENCE_60_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Zhang~EX.~E_Bedard~EE.L.~E_Potter~ER.~E_Zhong~ER.~E_Alam~EJ.~E_Choi~EA.M._and~Kbr_~H~M~2~1Lee~EP.J.~Kbr_~H~M~2~1TITLE_Mitogen~Factivated_protein_kinases_regulate_HO~F1_gene_transcription~Kbr_~H~M~2~1after_ischemia~Freperfusion_lung_injury~Kbr_~H~M~2~1JOURNAL_Am._J._Physiol._Lung_Cell_Mol._Physiol._283_~A4~B~E_L815~FL829_~A2002~B~Kbr_~H~M~2~1PUBMED_12225959~Kbr_~H~M~2~1REFERENCE_61_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Bak~EI.~E_Papp~EG.~E_Turoczi~ET.~E_Varga~EE.~E_Szendrei~EL.~E_Vecsernyes~EM.~E~Kbr_~H~M~2~1Joo~EF._and_Tosaki~EA.~Kbr_~H~M~2~1TITLE_The_role_of_heme_oxygenase~Frelated_carbon_monoxide_and_ventricular~Kbr_~H~M~2~1fibrillation_in_ischemic~Hreperfused_hearts~Kbr_~H~M~2~1JOURNAL_Free_Radic._Biol._Med._33_~A5~B~E_639~F648_~A2002~B~Kbr_~H~M~2~1PUBMED_12208350~Kbr_~H~M~2~1REMARK_GeneRIF~I_heme_oxygenase_has_a_role_in_prevention_of_reperfusion~Kbr_~H~M~2~1ventricular_fibrillation_via_an_increase_in_endogenous_carbon~Kbr_~H~M~2~1monoxide_production~Kbr_~H~M~2~1REFERENCE_62_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Ndisang~EJ.F.~E_Zhao~EW._and_Wang~ER.~Kbr_~H~M~2~1TITLE_Selective_regulation_of_blood_pressure_by_heme_oxygenase~F1_in~Kbr_~H~M~2~1hypertension~Kbr_~H~M~2~1JOURNAL_Hypertension_40_~A3~B~E_315~F321_~A2002~B~Kbr_~H~M~2~1PUBMED_12215473~Kbr_~H~M~2~1REMARK_GeneRIF~I_regulation_of_blood_pressure_by_heme_oxygenase~F1_in~Kbr_~H~M~2~1hypertension~Kbr_~H~M~2~1REFERENCE_63_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Tamion~EF.~E_Richard~EV.~E_Lacoume~EY._and_Thuillez~EC.~Kbr_~H~M~2~1TITLE_Intestinal_preconditioning_prevents_systemic_inflammatory_response~Kbr_~H~M~2~1in_hemorrhagic_shock._Role_of_HO~F1~Kbr_~H~M~2~1JOURNAL_Am._J._Physiol._Gastrointest._Liver_Physiol._283_~A2~B~E_G408~FG414~Kbr_~H~M~2~1~A2002~B~Kbr_~H~M~2~1PUBMED_12121889~Kbr_~H~M~2~1REFERENCE_64_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Carter~EE.P.~E_Hartsfield~EC.L.~E_Miyazono~EM.~E_Jakkula~EM.~E_Morris~EK.G.~Kbr_~H~M~2~1Jr._and_McMurtry~EI.F.~Kbr_~H~M~2~1TITLE_Regulation_of_heme_oxygenase~F1_by_nitric_oxide_during~Kbr_~H~M~2~1hepatopulmonary_syndrome~Kbr_~H~M~2~1JOURNAL_Am._J._Physiol._Lung_Cell_Mol._Physiol._283_~A2~B~E_L346~FL353_~A2002~B~Kbr_~H~M~2~1PUBMED_12114196~Kbr_~H~M~2~1REFERENCE_65_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Yang~EG.~E_Shegog~EM.L._and_Dennery~EP.A.~Kbr_~H~M~2~1TITLE_Effect_of_glutathione_on_lung_activator_protein~F1_activation_and~Kbr_~H~M~2~1heme_oxygenase~F1_induction_in_the_immature_rat~Kbr_~H~M~2~1JOURNAL_Pediatr._Res._52_~A1~B~E_34~F39_~A2002~B~Kbr_~H~M~2~1PUBMED_12084844~Kbr_~H~M~2~1REMARK_GeneRIF~I_the_neonatal_lung_is_relatively_resistant_to_AP~F1~Kbr_~H~M~2~1activation_and_Heme_oxygenase~F1_induction_by_GSH_perturbation.~Kbr_~H~M~2~1REFERENCE_66_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Peyton~EK.J.~E_Reyna~ES.V.~E_Chapman~EG.B.~E_Ensenat~ED.~E_Liu~EX.M.~E~Kbr_~H~M~2~1Wang~EH.~E_Schafer~EA.I._and_Durante~EW.~Kbr_~H~M~2~1TITLE_Heme_oxygenase~F1~Fderived_carbon_monoxide_is_an_autocrine_inhibitor~Kbr_~H~M~2~1of_vascular_smooth_muscle_cell_growth~Kbr_~H~M~2~1JOURNAL_Blood_99_~A12~B~E_4443~F4448_~A2002~B~Kbr_~H~M~2~1PUBMED_12036874~Kbr_~H~M~2~1REMARK_GeneRIF~I_Heme_oxygenase~F1~Fderived_carbon_monoxide_is_an_autocrine~Kbr_~H~M~2~1inhibitor_of_vascular_smooth_muscle_cell_growth.~Kbr_~H~M~2~1REFERENCE_67_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Sugishima~EM.~E_Sakamoto~EH.~E_Kakuta~EY.~E_Omata~EY.~E_Hayashi~ES.~E~Kbr_~H~M~2~1Noguchi~EM._and_Fukuyama~EK.~Kbr_~H~M~2~1TITLE_Crystal_structure_of_rat_apo~Fheme_oxygenase~F1_~AHO~F1~B~I_mechanism_of~Kbr_~H~M~2~1heme_binding_in_HO~F1_inferred_from_structural_comparison_of_the_apo~Kbr_~H~M~2~1and_heme_complex_forms~Kbr_~H~M~2~1JOURNAL_Biochemistry_41_~A23~B~E_7293~F7300_~A2002~B~Kbr_~H~M~2~1PUBMED_12044160~Kbr_~H~M~2~1REMARK_GeneRIF~I_The_structural_features_of_apo~Fheme_oxygenase~F1_~AHO~F1~B~Kbr_~H~M~2~1suggest_that_the_orientation_of_the_proximal_helix_and_the_position~Kbr_~H~M~2~1of_His25_~Athe_proximal_ligand_of_heme~B_are_fixed_upon_heme_binding.~Kbr_~H~M~2~1REFERENCE_68_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Zhang~EM.~E_Zhang~EB.H.~E_Chen~EL._and_An~EW.~Kbr_~H~M~2~1TITLE_Overexpression_of_heme_oxygenase~F1_protects_smooth_muscle_cells~Kbr_~H~M~2~1against_oxidative_injury_and_inhibits_cell_proliferation~Kbr_~H~M~2~1JOURNAL_Cell_Res._12_~A2~B~E_123~F132_~A2002~B~Kbr_~H~M~2~1PUBMED_12118938~Kbr_~H~M~2~1REMARK_GeneRIF~I_HO~F1_is_potentially_able_to_reduce_the_risk_factors_of~Kbr_~H~M~2~1atherosclerosis~E_partially_due_to_its_cellular_protection_against~Kbr_~H~M~2~1oxidative_injury_and_to_its_inhibitory_effect_on_cellular~Kbr_~H~M~2~1proliferation~Kbr_~H~M~2~1REFERENCE_69_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Kreiser~ED.~E_Nguyen~EX.~E_Wong~ER.~E_Seidman~ED.~E_Stevenson~ED.~E_Quan~ES.~E~Kbr_~H~M~2~1Abraham~EN._and_Dennery~EP.A.~Kbr_~H~M~2~1TITLE_Heme_oxygenase~F1_modulates_fetal_growth_in_the_rat~Kbr_~H~M~2~1JOURNAL_Lab._Invest._82_~A6~B~E_687~F692_~A2002~B~Kbr_~H~M~2~1PUBMED_12065678~Kbr_~H~M~2~1REMARK_GeneRIF~I_In_rats~E_heme_oxygenase~F1_modulates_fetal_growth_by_its~Kbr_~H~M~2~1effect_on_placental_growth_factors.~Kbr_~H~M~2~1REFERENCE_70_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Koike~EE.~E_Hirano~ES.~E_Shimojo~EN._and_Kobayashi~ET.~Kbr_~H~M~2~1TITLE_cDNA_microarray_analysis_of_gene_expression_in_rat_alveolar~Kbr_~H~M~2~1macrophages_in_response_to_organic_extract_of_diesel_exhaust~Kbr_~H~M~2~1particles~Kbr_~H~M~2~1JOURNAL_Toxicol._Sci._67_~A2~B~E_241~F246_~A2002~B~Kbr_~H~M~2~1PUBMED_12011483~Kbr_~H~M~2~1REMARK_GeneRIF~I_Exposure_to_diesel_exhaust_particles_elevated~Kbr_~H~M~2~1transcription_of_heme_oxygenase~F1_gene_in_rat_alveolar_macrophages.~Kbr_~H~M~2~1REFERENCE_71_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Almeida~EC._and_Branco~ES.~Kbr_~H~M~2~1TITLE_Role_of_the_haem_oxygenase~Fcarbon_monoxide_pathway_in~Kbr_~H~M~2~1insulin~Finduced_hypothermia~I_evidence_for_carbon_monoxide~Kbr_~H~M~2~1involvement~Kbr_~H~M~2~1JOURNAL_Pflugers_Arch._444_~A1~F2~B~E_244~F250_~A2002~B~Kbr_~H~M~2~1PUBMED_11976938~Kbr_~H~M~2~1REMARK_GeneRIF~I_carbon_monoxide_is_the_heme_oxygenase_product_involved_in~Kbr_~H~M~2~1the_thermoregulatory_effect_of_insulin~Finduced_hypothermia~Kbr_~H~M~2~1REFERENCE_72_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Hori~ER.~E_Kashiba~EM.~E_Toma~ET.~E_Yachie~EA.~E_Goda~EN.~E_Makino~EN.~E~Kbr_~H~M~2~1Soejima~EA.~E_Nagasawa~ET.~E_Nakabayashi~EK._and_Suematsu~EM.~Kbr_~H~M~2~1TITLE_Gene_transfection_of_H25A_mutant_heme_oxygenase~F1_protects_cells~Kbr_~H~M~2~1against_hydroperoxide~Finduced_cytotoxicity~Kbr_~H~M~2~1JOURNAL_J._Biol._Chem._277_~A12~B~E_10712~F10718_~A2002~B~Kbr_~H~M~2~1PUBMED_11786534~Kbr_~H~M~2~1REMARK_GeneRIF~I_Gene_transfection_of_H25A_mutant_heme_oxygenase~F1_protects~Kbr_~H~M~2~1cells_against_hydroperoxide~Finduced_cytotoxicity~Kbr_~H~M~2~1REFERENCE_73_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Masuko~EY.~Kbr_~H~M~2~1TITLE_~PImpact_of_stress_response_genes_induced_by_L~Fglutamine_on_warm~Kbr_~H~M~2~1ischemia_and_reperfusion_injury_in_the_rat_small_intestine~Q~Kbr_~H~M~2~1JOURNAL_Hokkaido_Igaku_Zasshi_77_~A2~B~E_169~F183_~A2002~B~Kbr_~H~M~2~1PUBMED_11968853~Kbr_~H~M~2~1REMARK_GeneRIF~I_has_an_anti~Foxidative_function~Kbr_~H~M~2~1REFERENCE_74_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Steiner~EA.A._and_Branco~EL.G.~Kbr_~H~M~2~1TITLE_Role_of_the_preoptic_carbon_monoxide_pathway_in_endotoxin_fever_in~Kbr_~H~M~2~1rats~Kbr_~H~M~2~1JOURNAL_Brain_Res._927_~A1~B~E_27~F34_~A2002~B~Kbr_~H~M~2~1PUBMED_11814429~Kbr_~H~M~2~1REMARK_GeneRIF~I_Heme_Oxygenase~FCarbon_monoxide_pathway_in_the_preoptic~Kbr_~H~M~2~1region_of_the_anterior_hypothalamus_is_not_involved_in_fever~Kbr_~H~M~2~1REFERENCE_75_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Ozawa~EN.~E_Goda~EN.~E_Makino~EN.~E_Yamaguchi~ET.~E_Yoshimura~EY._and~Kbr_~H~M~2~1Suematsu~EM.~Kbr_~H~M~2~1TITLE_Leydig_cell~Fderived_heme_oxygenase~F1_regulates_apoptosis_of~Kbr_~H~M~2~1premeiotic_germ_cells_in_response_to_stress~Kbr_~H~M~2~1JOURNAL_J._Clin._Invest._109_~A4~B~E_457~F467_~A2002~B~Kbr_~H~M~2~1PUBMED_11854317~Kbr_~H~M~2~1REFERENCE_76_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Shepard~EM.~E_Dhulipala~EP.~E_Kabaria~ES.~E_Abraham~EN.G._and_Lianos~EE.A.~Kbr_~H~M~2~1TITLE_Heme_oxygenase~F1_localization_in_the_rat_nephron~Kbr_~H~M~2~1JOURNAL_Nephron_92_~A3~B~E_660~F664_~A2002~B~Kbr_~H~M~2~1PUBMED_12372951~Kbr_~H~M~2~1REMARK_GeneRIF~I_distal_and_collecting_tubular_cells_were_identified_as_the~Kbr_~H~M~2~1main_segments_of_the_nephron_that_express_HO~F1_so_that_the_distal~Kbr_~H~M~2~1nephron_may_be_less_vulnerable_to_oxidative_injury.~Kbr_~H~M~2~1REFERENCE_77_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Sahlas~ED.J.~E_Liberman~EA._and_Schipper~EH.M.~Kbr_~H~M~2~1TITLE_Role_of_heme_oxygenase~F1_in_the_biogenesis_of_corpora_amylacea~Kbr_~H~M~2~1JOURNAL_Biogerontology_3_~A4~B~E_223~F231_~A2002~B~Kbr_~H~M~2~1PUBMED_12232504~Kbr_~H~M~2~1REMARK_GeneRIF~I_Role_of_heme_oxygenase~F1_in_the_biogenesis_of_corpora~Kbr_~H~M~2~1amylacea~Kbr_~H~M~2~1REFERENCE_78_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Kato~EH.~E_Amersi~EF.~E_Buelow~ER.~E_Melinek~EJ.~E_Coito~EA.J.~E_Ke~EB.~E~Kbr_~H~M~2~1Busuttil~ER.W._and_Kupiec~FWeglinski~EJ.W.~Kbr_~H~M~2~1TITLE_Heme_oxygenase~F1_overexpression_protects_rat_livers_from~Kbr_~H~M~2~1ischemia~Hreperfusion_injury_with_extended_cold_preservation~Kbr_~H~M~2~1JOURNAL_Am_J_Transplant_1_~A2~B~E_121~F128_~A2001~B~Kbr_~H~M~2~1PUBMED_12099359~Kbr_~H~M~2~1REMARK_GeneRIF~I_overexpression_protects_rat_livers_from~Kbr_~H~M~2~1ischemia~Hreperfusion_injury_with_extended_cold_preservation~Kbr_~H~M~2~1REFERENCE_79_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Maines~EM.D._and_Panahian~EN.~Kbr_~H~M~2~1TITLE_The_heme_oxygenase_system_and_cellular_defense_mechanisms._Do_HO~F1~Kbr_~H~M~2~1and_HO~F2_have_different_functions~N~Kbr_~H~M~2~1JOURNAL_Adv._Exp._Med._Biol._502~E_249~F272_~A2001~B~Kbr_~H~M~2~1PUBMED_11950143~Kbr_~H~M~2~1REMARK_GeneRIF~I_HO~F1_may_afford_protection_against_tissue_damage_by_prompt~Kbr_~H~M~2~1response_to_the_increased_demand_for_heme_catalysis~E_as_well_as~Kbr_~H~M~2~1contribution_to_controlled_cell_death_through_intrinsic_suicide~Kbr_~H~M~2~1program~Kbr_~H~M~2~1REFERENCE_80_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Datta~EP.K.~E_Koukouritaki~ES.B.~E_Hopp~EK.A._and_Lianos~EE.A.~Kbr_~H~M~2~1TITLE_Heme_oxygenase~F1_induction_attenuates_inducible_nitric_oxide~Kbr_~H~M~2~1synthase_expression_and_proteinuria_in_glomerulonephritis~Kbr_~H~M~2~1JOURNAL_J._Am._Soc._Nephrol._10_~A12~B~E_2540~F2550_~A1999~B~Kbr_~H~M~2~1PUBMED_10589693~Kbr_~H~M~2~1REMARK_GeneRIF~I_Heme_oxygenase~F1_induction_attenuates_inducible_nitric~Kbr_~H~M~2~1oxide_synthase_expression_and_proteinuria_in_glomerulonephritis.~Kbr_~H~M~2~1REFERENCE_81_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Muller~ER.M.~E_Taguchi~EH._and_Shibahara~ES.~Kbr_~H~M~2~1TITLE_Nucleotide_sequence_and_organization_of_the_rat_heme_oxygenase_gene~Kbr_~H~M~2~1JOURNAL_J._Biol._Chem._262_~A14~B~E_6795~F6802_~A1987~B~Kbr_~H~M~2~1PUBMED_3032976~Kbr_~H~M~2~1REFERENCE_82_~Abases_1_to_1600~B~Kbr_~H~M~2~1AUTHORS_Shibahara~ES.~E_Muller~ER.~E_Taguchi~EH._and_Yoshida~ET.~Kbr_~H~M~2~1TITLE_Cloning_and_expression_of_cDNA_for_rat_heme_oxygenase~Kbr_~H~M~2~1JOURNAL_Proc._Natl._Acad._Sci._U.S.A._82_~A23~B~E_7865~F7869_~A1985~B~Kbr_~H~M~2~1PUBMED_3865203~Kbr_~H~M~2~1COMMENT_PROVISIONAL_REFSEQ~I_This_record_has_not_yet_been_subject_to_final~Kbr_~H~M~2~1NCBI_review._The_reference_sequence_was_derived_from_BC091164.1.~Kbr_~H~M~2~1On_Mar_13~E_2005_this_sequence_version_replaced_gi~I6981031.~Kbr_~H~M~2~1~Kbr_~H~M~2~1SUMMARY~I_catalyzes_the_oxidative_cleavage_of_heme_to_biliverdin~Kbr_~H~M~2~1~PRGD~Q.~Kbr_~H~M~2~1FEATURES_Location~HQualifiers~Kbr_~H~M~2~1source_1..1600~Kbr_~H~M~2~1~Horganism~L~4Rattus_norvegicus~4~Kbr_~H~M~2~1~Hmol~Stype~L~4mRNA~4~Kbr_~H~M~2~1~Hdb~Sxref~L~4taxon~I10116~4~Kbr_~H~M~2~1~Hchromosome~L~419~4~Kbr_~H~M~2~1~Hmap~L~419p11~4~Kbr_~H~M~2~1gene_1..1600~Kbr_~H~M~2~1~Hgene~L~4Hmox1~4~Kbr_~H~M~2~1~Hnote~L~4synonyms~I_Ho1~E_Heox~E_Hmox~E_Ho~F1~E_HEOXG~E_hsp32~4~Kbr_~H~M~2~1~Hdb~Sxref~L~4GeneID~I24451~4~Kbr_~H~M~2~1~Hdb~Sxref~L~4RATMAP~I34040~4~Kbr_~H~M~2~1~Hdb~Sxref~L~4RGD~I2806~4~Kbr_~H~M~2~1CDS_117..986~Kbr_~H~M~2~1~Hgene~L~4Hmox1~4~Kbr_~H~M~2~1~Hnote~L~4heme_oxygenase_1~J_Heme_oxygenase_1~J~Kbr_~H~M~2~1go~Scomponent~I_microsome_~Pgoid_0005792~Q_~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Scomponent~I_plasma_membrane_~Pgoid_0005886~Q_~Pevidence~Kbr_~H~M~2~1IEA~Q~J~Kbr_~H~M~2~1go~Scomponent~I_membrane_fraction_~Pgoid_0005624~Q_~Pevidence~Kbr_~H~M~2~1IEA~Q~J~Kbr_~H~M~2~1go~Scomponent~I_plasma_membrane_~Pgoid_0005886~Q_~Pevidence~Kbr_~H~M~2~1TAS~Q_~Ppmid_12511545~Q~J~Kbr_~H~M~2~1go~Scomponent~I_integral_to_membrane_~Pgoid_0016021~Q~Kbr_~H~M~2~1~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Scomponent~I_endoplasmic_reticulum_~Pgoid_0005783~Q~Kbr_~H~M~2~1~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sfunction~I_heme_binding_~Pgoid_0020037~Q_~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sfunction~I_heme_binding_~Pgoid_0020037~Q_~Pevidence_IDA~Q~Kbr_~H~M~2~1~Ppmid_12044160~Q~J~Kbr_~H~M~2~1go~Sfunction~I_oxidoreductase_activity_~Pgoid_0016491~Q~Kbr_~H~M~2~1~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sfunction~I_phospholipase_D_activity_~Pgoid_0004630~Q~Kbr_~H~M~2~1~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sfunction~I_signal_transducer_activity_~Pgoid_0004871~Q~Kbr_~H~M~2~1~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sfunction~I_oxidoreductase_activity_~Pgoid_0016491~Q~Kbr_~H~M~2~1~Pevidence_IDA~Q_~Ppmid_12114196~Q~J~Kbr_~H~M~2~1go~Sfunction~I_phospholipase_D_activity_~Pgoid_0004630~Q~Kbr_~H~M~2~1~Pevidence_IDA~Q_~Ppmid_12511545~Q~J~Kbr_~H~M~2~1go~Sfunction~I_heme_oxygenase_~Adecyclizing~B_activity_~Pgoid~Kbr_~H~M~2~10004392~Q_~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sfunction~I_heme_oxygenase_~Adecyclizing~B_activity_~Pgoid~Kbr_~H~M~2~10004392~Q_~Pevidence_IDA~Q_~Ppmid_11854317~Q~J~Kbr_~H~M~2~1go~Sfunction~I_heme_oxygenase_~Adecyclizing~B_activity_~Pgoid~Kbr_~H~M~2~10004392~Q_~Pevidence_TAS~Q_~Ppmid_12114196~Q~J~Kbr_~H~M~2~1go~Sprocess~I_heme_oxidation_~Pgoid_0006788~Q_~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sprocess~I_heme_oxidation_~Pgoid_0006788~Q_~Pevidence_TAS~Q~Kbr_~H~M~2~1~Ppmid_12114196~Q~J~Kbr_~H~M~2~1go~Sprocess~I_response_to_stimulus_~Pgoid_0050896~Q_~Pevidence~Kbr_~H~M~2~1IEA~Q~J~Kbr_~H~M~2~1go~Sprocess~I_phospholipid_metabolism_~Pgoid_0006644~Q~Kbr_~H~M~2~1~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sprocess~I_phospholipid_metabolism_~Pgoid_0006644~Q~Kbr_~H~M~2~1~Pevidence_TAS~Q_~Ppmid_12511545~Q~J~Kbr_~H~M~2~1go~Sprocess~I_intracellular_signaling_cascade_~Pgoid_0007242~Q~Kbr_~H~M~2~1~Pevidence_IDA~Q_~Ppmid_12225959~Q~J~Kbr_~H~M~2~1go~Sprocess~I_small_GTPase_mediated_signal_transduction~Kbr_~H~M~2~1~Pgoid_0007264~Q_~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sprocess~I_small_GTPase_mediated_signal_transduction~Kbr_~H~M~2~1~Pgoid_0007264~Q_~Pevidence_IDA~Q_~Ppmid_12511545~Q~J~Kbr_~H~M~2~1go~Sprocess~I_positive_regulation_of_I~FkappaB~Kbr_~H~M~2~1kinase~HNF~FkappaB_cascade_~Pgoid_0043123~Q_~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sprocess~I_DNA_damage_response~E_signal_transduction~Kbr_~H~M~2~1resulting_in_induction_of_apoptosis_~Pgoid_0008630~Q~Kbr_~H~M~2~1~Pevidence_IEA~Q~J~Kbr_~H~M~2~1go~Sprocess~I_DNA_damage_response~E_signal_transduction~Kbr_~H~M~2~1resulting_in_induction_of_apoptosis_~Pgoid_0008630~Q~Kbr_~H~M~2~1~Pevidence_IDA~Q_~Ppmid_11854317~Q~4~Kbr_~H~M~2~1~Hcodon~Sstart~L1~Kbr_~H~M~2~1~Hproduct~L~4heme_oxygenase_~Adecycling~B_1~4~Kbr_~H~M~2~1~Hprotein~Sid~L~4NP~S036712.1~4~Kbr_~H~M~2~1~Hdb~Sxref~L~4GI~I6981032~4~Kbr_~H~M~2~1~Hdb~Sxref~L~4GeneID~I24451~4~Kbr_~H~M~2~1~Hdb~Sxref~L~4RATMAP~I34040~4~Kbr_~H~M~2~1~Hdb~Sxref~L~4RGD~I2806~4~Kbr_~H~M~2~1~Htranslation~L~4MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSR~Kbr_~H~M~2~1EGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQ~Kbr_~H~M~2~1EAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSS~Kbr_~H~M~2~1GEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQ~Kbr_~H~M~2~1ALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLS~Kbr_~H~M~2~1FLLATVAVGIYAM~4~Kbr_~H~M~2~1ORIGIN~Kbr_~H~M~2~11_cgcctccaga_gtttccgcct_ccaaccagcg_agtggagcct_gccggagcag_agccatctcg~Kbr_~H~M~2~161_agcggagccc_ggagcctgaa_gcgagcggag_ccagcctgaa_ctagcccagt_cccgcgatgg~Kbr_~H~M~2~1121_agcgcccaca_gctcgacagc_atgtcccagg_atttgtccga_ggccttgaag_gaggccacca~Kbr_~H~M~2~1181_aggaggtgca_catccgtgca_gagaattctg_agttcatgag_gaactttcag_aagggtcagg~Kbr_~H~M~2~1241_tgtccaggga_aggctttaag_ctggtgatgg_cctccttgta_ccatatctat_acggccctgg~Kbr_~H~M~2~1301_aagaggagat_agagcgaaac_aagcagaacc_cagtctatgc_cccactctac_ttccctgagg~Kbr_~H~M~2~1361_agctgcaccg_aagggctgcc_ctagagcagg_acatggcctt_ctggtatggg_ccccactggc~Kbr_~H~M~2~1421_aggaggccat_cccttacaca_ccagccacac_agcactacgt_aaagcgtctc_cacgaggtgg~Kbr_~H~M~2~1481_gaggtactca_tcctgagctg_ctggtggccc_acgcatatac_ccgctacctg_ggtgacctct~Kbr_~H~M~2~1541_cagggggtca_ggtcctgaag_aagattgcgc_agaaggccat_ggccttgcca_agctctgggg~Kbr_~H~M~2~1601_aaggcctggc_ttttttcacc_ttcccgagca_tcgacaaccc_caccaagttc_aaacagctct~Kbr_~H~M~2~1661_atcgtgctcg_catgaacact_ctggagatga_cccccgaggt_caagcacagg_gtgacagaag~Kbr_~H~M~2~1721_aggctaagac_cgccttcctg_ctcaacattg_agctgtttga_ggagctgcag_gcactgctga~Kbr_~H~M~2~1781_cagaggaaca_caaagaccag_agtccctcac_agacagagtt_tcttcgccag_aggcctgcta~Kbr_~H~M~2~1841_gcctggttca_agatactacc_tctgcagaga_cgccccgagg_aaaatcccag_atcagcacta~Kbr_~H~M~2~1901_gttcatccca_gacaccgctc_ctgcgatggg_tcctcacact_cagtttcctg_ttggcgaccg~Kbr_~H~M~2~1961_tggcagtggg_aatttatgcc_atgtaaatgc_agtgttggcc_cccagaggct_gtgaactctg~Kbr_~H~M~2~11021_tctcatgtag_ccttctctct_gcaggggaga_atcttgcctg_gctctctttt_cttgggcctc~Kbr_~H~M~2~11081_taagaaagct_tttggggttc_ctcgccccct_tcctgtgtct_tcctttgtct_ctctggaatg~Kbr_~H~M~2~11141_gaaggagatg_cctggcacat_ttccctcacc_aaaagcacag_ccaggggcct_gaacttggaa~Kbr_~H~M~2~11201_accagcagcc_ccaaatcctg_caacagagcc_ccagaactgt_ggtcggtaga_ggcggctgtt~Kbr_~H~M~2~11261_ctgagcccag_tgcccttggt_agtcggcgtc_catgttgact_gaccatgact_gctttccccc~Kbr_~H~M~2~11321_agcgtcatgg_ccactttgat_atcagtgtgc_agagattttc_tgtcttgtgt_ttctgtcttg~Kbr_~H~M~2~11381_tttttgttat_ttccccagtt_ctaccagtgt_aatggtattt_tttgttgtat_cgattgtttt~Kbr_~H~M~2~11441_tttattctaa_ccaagtaggg_ctgtcttttg_aggggtgggt_ggtatttaat_aattgtaacc~Kbr_~H~M~2~11501_ttggtctcta_acttctgtgt_gaaataataa_atggcattat_ctaataaaaa_aaaaaaaaaa~Kbr_~H~M~2~11561_aaaaaaaaaa_aaaaaaaaaa_aaaaaaaaaa_aaaaaaaaaa~Kbr_~H~M~2~1~H~H
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