Liver Slice Technology as an In Vitro Model for Metabolic and Toxicity Studies

Liver Slice Technology is a relatively new addition to the battery of in vitro assays of xenobiotic metabolism and toxicity evaluation. As with any developing technology, evaluation and refinement of the technique will be an essential component of its implementation to routine use. Three goals of this article will be to: (1 ) provide a brief survey of currently used methods for immediate and cultured liver slices, (2 ) review the use of liver slices in the assessment and quantification of pharmacological and toxicological responses, and (3) discuss the possible use of Liver Slice Technology for the investigation of drug interactions.