Myocardial Ischemia-Reperfusion Injury and Proteolysis of Fodrin, Ankyrin, and Calpastatin
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Erythrocyte spectrin and nonerythroid spectrin (fodrin, calspectin) are major constituents of the membrane cytoskeleton, forming
a two-dimensional meshwork beneath the outer cell membrane (
1
,
2
). The three-dimensional organization of the membrane cytoskeleton has been extensively studied in the erythrocyte, providing
a model shown in (Fig.1
) (
1
). Spectrin and fodrin are rod-shaped proteins and consist of α and β subunits (several isoforms exist) (
1
).
Fig. 1.
Schematic representation of the organization of spectrin cytoskeleton of erythrocyte.
