α-Oligodeoxynucleotides
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Monomeric units of nucleic acids DN A or RN A are characterized by a β configuration at the anomeric center of the sugar moiety (Fig. 1 ). Natural constitutive nucleosides of this configuration are readily commercially available, and from such starting building blocks, numerous phosphate-backbone-modified oligonucleotides have been proposed, the most well known being the methylphosphonate and the phosphorothioate series ( 1 ).
Fig. 1. Monomeric structure of oligonucleotides.
