Guselkumab古塞库单抗古塞库单抗,1350289-8

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Guselkumab

CAS No. : 1350289-85-8

MCE 国际站：Guselkumab

产品活性：Guselkumab 是一种重组人 IgG1 单克隆抗体，针对 IL-23p19 亚基。Guselkumab 与人和食蟹猴 IL-23 的结合值 K_d 分别为 3.3 pM 和 1.9 pM。Guselkumab 抑制 IL-23 信号通路下游细胞因子的产生，可用于银屑病关节炎的研究。

研究领域：Immunology/Inflammation

作用靶点：Interleukin Related

In Vitro: Guselkumab inhibits IL-23 (0.5 or 1 ng/mL)-mediated production of Th17 cytokines IL17A, IL-17F, and IL-22 in mouse splenocyteswith IC₅₀ ranging 0.016-0.080 nM. And, it inhibits IL-23 (10 or 100 ng/mL)-mediated production of IL-10 in human NKL cells. Guselkumab has no effect on IL-12 (0.1 ng/mL)-mediated production of interferon γ (IFNγ) in NK92MI cells. .
Guselkumab combines with IBI112 blocks IL-23-induced STAT3 phosphorylation, and Guselkumab blocks IL-23-induced STAT3 phosphorylation with an IC₅₀ value of 102.1100±2.0053 nM.
. Guselkumab blocks hIL-23-induced mIL-17 production in a dose-dependent manner, exhibiting an IC₅₀ of 4.9743 ±1.2847 nM. In another experiment, Guselkumab also blocks IL-17F production in cynomolgus monkeys with an IC₅₀ of 16.7950 nM.

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