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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
316173-57-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1100.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥419.0 |
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1700.0 |
| 规格： | 25 mg | 产品价格： | ￥3000.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
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SCH442416
CAS No. : 316173-57-6
MCE 国际站：SCH442416
产品活性：SCH442416 是一种有效，选择性和可透过血脑屏障的腺苷 A2A 受体 (A2AR) 拮抗剂，对人和大鼠 A2AR 的 Ki 值分别为 0.048 和 0.5 nM。SCH442416 在 A1R，A2BR 和 A3R (Ki=1111，10000，10000 nM) 上显示出超过 23000 倍的选择性。SCH442416 可用于在大鼠和灵长类动物大脑中对腺苷 A2A 受体成像。
研究领域：GPCR/G Protein
作用靶点：Adenosine Receptor
In Vitro: SCH442416 is selective for A2AR (Ki=0.50 nM) in rat striatal membranes over A1R and A3R (Ki=1815 and >10000, respectively).
SCH442416 (0.1-10 μM) increases the glutamine synthetase (GS) and glutamate aspartate transporter (GLAST) proteins expression of Müller cells in Group 1 μM.
In Vivo: SCH-442416 (0.017 mg/kg; i.p.) completely abrogates the CGS-21680-induced decrease in skeletal muscle injury.
SCH-442416 (1 μM•2μL; i.v.) increases the GS and GLAST protein expression in rats.
SCH442416 (1 μM) significantly attenuates the adenosine-induced dilation (from 15.3 to 5.6 μm).
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文献和实验Signal Transduction Inhibitors in Cellular Function
CAAX peptide analogues BZA-5B, L-739, Cys-4-ABA-Met FT1-276, SCH44342, SCH66336 (57 –59) Bisubstrate inhibitors
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Characterization of Dopamine Receptors
Membrane preparation (see protocol 4 or protocol 52 ) [3 H]SCH 23390 assay buffer (see recipe )
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