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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
ERK-IN-3
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2055597-12-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1564.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥571.0 |
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2475.0 |
| 规格： | 25 mg | 产品价格： | ￥4084.0 |
| 规格： | 50 mg | 产品价格： | ￥5717.0 |
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ASN007
CAS No. : 2055597-12-9
MCE 国际站：ASN007
产品活性：ASN007 (ERK-IN-3) 是一种有效和具有口服活性的 ERK 抑制剂。 ASN007 以较低的 IC50 值抑制 ERK1/2。 ASN007 可用于研究由 RAS 突变驱动的癌症。
研究领域：MAPK/ERK Pathway | Stem Cell/Wnt
作用靶点：ERK
In Vitro: ASN007 (ERK-IN-3) inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines.
ASN007 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines.
In Vivo: ASN007 (ERK-IN-3) (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses.
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