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- 保存条件:
-20°C, sealed storage, away from moisture
- 英文名:
ERK-IN-3 benzenesulfonate
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
2055597-39-0
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥2086.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥681.0 |
| 规格: | 5 mg | 产品价格: | ¥1500.0 |
| 规格: | 10 mg | 产品价格: | ¥2500.0 |
| 规格: | 25 mg | 产品价格: | ¥5500.0 |
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ASN007 benzenesulfonate
CAS No. : 2055597-39-0
MCE 国际站:ASN007 benzenesulfonate
产品活性:ASN007 (ERK-IN-3) benzenesulfonate 是一种有效和具有口服活性的 ERK 抑制剂。 ASN007 benzenesulfonate 以较低的 IC50 值抑制 ERK1/2。 ASN007 benzenesulfonate 可用于研究由 RAS 突变驱动的癌症。
研究领域:MAPK/ERK Pathway | Stem Cell/Wnt
作用靶点:ERK
In Vitro: ASN007 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines.
ASN007 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines.
In Vivo: ASN007 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses.
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文献和实验DataMatrix对象中,每行对应一个HuGeneFl芯片的探针集,每列对应于一个样本,行名是探针集的ID而列名为样本名,本文用expr_cns_gcrma_eb示例,当然也可以用其他对象。 调用get命令获取DataMatrix对象的特征。 get(expr_cns_gcrma_eb) Name: 39;CNS gene expression data39; RowNames: {7129x1 cell} ColNames: {1x42
子表 氨基酸 密码 频率 氨基酸 密码 频率 Leu TTA 15.6 His CAT 11.9 TTG 31.2 CAC 9.1 CTT 15.7 Gln CAA 25.3 CTC 7.5 CAG 16.2 CTA 10.9 Asn
codons, dividing it into three regions: preS1, preS2, and S ( 1 , 2 ). The three envelope proteins are referred to in the literature as large (L) (p39/gp42), middle (M) (gp33/gp36), and small (S, major surface antigen) (p24/gp27) envelope
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