- ￥4800
- Tanda
- 美国
- TD-26200
- 2025年10月27日
- ELISA,WB
- Mouse
- 脊椎动物
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A synthetic peptide from the internal region of BRAF which includes the mutation of D594G, human
- 亚型：
lgG
- 形态：
液体
- 保存条件：
-20℃
- 克隆性：
单克隆
- 标记物：
FITC
- 适应物种：
脊椎动物
- 保质期：
24个月
- 抗原来源：
蛋白
- 目录编号：
TD-26200
- 级别：
科研级
- 库存：
999
- 供应商：
武汉天德
- 宿主：
Mouse
- 应用范围：
ELISA,WB
- 浓度：
1mg/ml
- 靶点：
D594G
- 抗体英文名：
Anti-B-Raf (D594G) mouse monoclonal antibody
- 抗体名：
BRAF (D594G)
- 规格：
100 μL
BRAF(D594G)
| Cat. #: TD-26200 |
| Gene Symbol: BRAF, BRAF1, RAFB1 |
| Description: Anti-BRAF(D594G) Mouse Monoclonal Antibody |
| Background: BRAF belongs to a family of serine-threonine protein kinases. As a part of a signaling pathway known as the the RAS/MAPK pathway, it plays an important part in many cellular processes. The processes include cell proliferation, differentiation and transcriptional regulation. Mutations in the BRAF gene cause diseases. Inherited mutations in BRAF cause cardiofaciocutaneous syndrome. Acquired mutations in BRAF have been found in cancers. |
| Immunogen: A synthetic peptide from the internal region of BRAF which includes the mutation of D594G, human origin. |
| Applications: ELISA, WB |
| Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:500-1:1000 |
| Concentration: 1 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Recognizes D594G mutant, but not wild type BRAF of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
| Western blot: 
|
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文献和实验或可疑恶性患者的术后病理发现，仅20%~25%为甲状腺癌，而另75%~80%的患者则接受了不必要的甲状腺手术[3]。因此，如何正确处理这些FNAB无法确诊的病例，是目前面临的最大困难和挑战。 BRAF V600E是一个突出的PTC癌基因，占BRAF基因突变的80%，BRAF基因突变对PTC具有较好的特异性，BRAF突变阳性,几乎就可以确诊为PTC。因此，BRAF V600E对于乳头状甲状腺瘤来说是一种重要的诊断标记物，可以指导医师为细胞学诊断不能确诊的患者选择最佳的治疗方案。 表
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