背景知识 EDN(嗜酸性粒细胞源性神经毒素,也称为RNASE2或嗜酸性粒细胞蛋白x[EPX])是一种阳离子糖蛋白,由活化的嗜酸性粒细胞释放,具有很强的细胞毒性特征,在预防病毒感染中起着重要作用。它由嗜酸性粒细胞释放,主要存在嗜酸性粒细胞较多的地方,如皮肤、肺、泌尿生殖道和胃肠道,即作为病原体入口的器官。肠内EDN的积累与炎症和组织损伤有关。测量粪便中的EDN可作为当前临床或亚临床胃肠道慢性炎症的客观参数。对于溃疡性结肠炎和克罗恩病,EDN测量能够评估疾病的活动并预测复发。 样本要求:血清、血浆、尿液和粪便 储存条件: 本产品在2-8℃下保存,可稳定至标签所示日期。 参考文献:1. Konikoff, M.R. et al., 2006. Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 4(11), pp.1328–36. 2. Lotfi, R. & Lotze, M.T., 2008. Eosinophils induce DC maturation, regulating immunity. Journal of leukocyte biology, 83(3), pp.456–60. 3. Bentz, S. et al., 2010. Clinical relevance of IgG antibodies against food antigens in Crohn’s disease: a double-blind cross-over diet intervention study. Digestion, 81(4), pp.252–64. 4. Kalach, N. et al., 2013. Intestinal permeability and fecal eosinophil-derived neurotoxin are the best diagnosis tools for digestive non-IgE-mediated cow’s milk allergy in toddlers. Clinical chemistry and laboratory medicine : CCLM / FESCC, 51(2), pp.351–61.