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Human Anti-antibody Response

on safety and efficacy. Therefore, assessment of immunogenicity of the therapeutic protein is an essential part of its clinical development. This involves testing strategies which provide relevant information on antibody responses. This chapter describes

Anticardiolipin Antibody and Anti-beta 2 Glycoprotein I Antibody Assays

) antibodies and anti-beta 2 glycoprotein I (β2-GPI) antibodies. Other autoantibodies, such as those directed against anionic phospholipids, can also be assayed; however they are not of clinical significance. Participation in a quality assurance

Anti-Idiotypic Antibodies That Mimic Opioids

to each other and to the G-protein-coupled receptor super-family. Before the successes in cloning the subclasses, several investigators seeking to answer questions about the molecular basis of the different opioid-receptor classes prepared anti-idiotypic antibodies