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文献和实验Mapping Inherited Diseases by Linkage Analysis
Family studies have provided experimental observations enabling geneticists to recognize many human genetic traits and diseases. Single-gene Mendelian traits are usually deduced by straightforward inspection of the data, but sophisticated
Inherited Complement Deficiencies in Animals
Animal models have been widely used to investigate the role of the complement system in a host of infectious and inflammatory diseases. Over the last 30 yr, a number of naturally occurring genetic deficiencies of complement components
Identification and Analysis of Inherited Retinal Disease Genes
Inherited retinal diseases display a very high degree of clinical and genetic heterogeneity, which poses challenges in identifying the underlying defects in known genes and in identifying novel retinal disease genes. Here, we outline
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