Neurotensin (trifluoroacetate

一种具有多种生物活性的神经肽；诱导大鼠体温过低（每小时10-50μg，侧脑室）；在冷水游泳压力测试中，野生型小鼠的信号传导增加并诱导镇痛；作为间接多巴胺拮抗剂，抑制多巴胺在突触前和突触后多巴胺受体上诱导的作用；抑制小肠蠕动和胃酸分泌，刺激胰腺和胆汁分泌，增加脂肪酸吸收，刺激大鼠胃、结肠、胰腺和小肠的生长；通过诱导IL-8分泌和激活EMT来促进癌细胞的生长（体外和体内）。A neuropeptide with diverse biological activities; induces hypothermia in rats (10-50 μg per hour, i.c.v.); signaling is increased and induces analgesia in wild-type mice in a cold water swim stress test; acts as an indirect dopamine antagonist that inhibits dopamine-induced effects at pre- and postsynaptic dopamine receptors; inhibits small bowel motility and secretion of gastric acid, stimulates pancreatic and biliary secretion, increases fatty acid absorption, and stimulates growth of the stomach, colon, pancreas, and small bowel in rats; increases growth of carcinoma cells via induction of IL-8 secretion and activation of EMT in vitro and in vivo.