Stavudine

HIV逆转录酶抑制剂；抑制PBMCs中的HIV-1复制（EC50=8.8nM）；在0.1-10µg/ml时降低MT-4细胞中HIV特异性抗原的合成；在0.05µg/ml时减少MT-4细胞中HIV诱导的斑块形成；降低HIV-2感染恒河猴的血浆和细胞相关病毒载量；在累积剂量为375mg/kg时在ATN大鼠模型中诱发持续性后爪机械性异常性疼痛。An inhibitor of HIV reverse transcriptase; inhibits HIV-1 replication in PBMCs (EC50 = 8.8 nM); reduces the synthesis of HIV-specific antigen in MT-4 cells at 0.1-10 µg/ml; reduces HIV-induced plaque formation in MT-4 cells at 0.05 µg/ml; reduces plasma- and cell-associated viral load in HIV-2-infected macaques; induces sustained hind paw mechanical allodynia in a rat model of ATN at a cumulative dose of 375 mg/kg.