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文献和实验Nature 重磅:新发脑胶质瘤疫苗初见成效,瞄准肿瘤「阿喀琉斯之踵」
,发挥抗肿瘤效应。该成果以 A vaccine targeting mutant IDH1 in newly diagnosed glioma 为题发表在最新的 Nature 上 [2]。 图片来源:Nature 研究内容:这是一项靶向 IDH1R132H 的多肽疫苗治疗 III-IV 级(WHO 分级)胶质瘤的安全性、耐受性和免疫原性的多中心 I 期临床研究(NCT02454634)。研究人员筛选了 44 名患者,其中 32 名患者入组参与了临床试验并接受了 IDH-vac 治疗。在这 32 名
Functional Analysis of Mutant Mitochondrial DNA Polymerase Proteins Involved in Human Disease
to disease. Furthermore, crucial knowledge concerning the role of pol γ in mtDNA replication and repair can be acquired. Here we present the protocols to characterize mutant DNA pol γ proteins, namely, assays for processive DNA synthesis, exonuclease activity
mechanisms. Collectively, these findings illustrate that knockout and mutant rats are very valuable in modeling human psychiatric disorders. Furthermore, exploitation of the rat’s advantages in measuring complex cognitive functions will complement mouse
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