hIL2，Interleukin-2 (IL2),

hIL2，Interleukin-2  (IL2),

Interleukin-2  (IL2),  also  known  as  a  T-cell  growth factor, TCGF, and Aldesleukin, is a secreted protein that  belongs  to  the  IL-2  family.  IL2  has  potent stimulatory activity for antigen-activated T cells, and is expressed by T cells, B cells, dendritic cells, and eosinophils.   Mature   human   IL-2   shares   56%   aa sequence identity with mouse IL-2. Human and mouse IL-2  exhibit  cross-species  activity.  The  receptor  for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. The 55  kDa IL-2 R alpha is specific for IL-2 and binds with  low affinity. The 75 kDa IL-2R beta, which is also a  component  of  the  IL-15  receptor,  binds  IL-2  with  intermediate  affinity.  The  64  kDa  common  gamma  chain gamma c/IL-2 R gamma, which is shared with  the receptors for IL-4, -7, -9, -15, and -21, does not  independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 R beta  and gamma c. IL-2 is best known for its autocrine and  paracrine activity on T cells. It drives resting T cells to  proliferate  and  induces  IL-2  and  IL-2  R  alpha synthesis.  It  contributes  to  T   cell  homeostasis  by promoting the Fas-induced  death  of naive  CD4+  T cells but not activated CD4+ memory lymphocytes . IL-2  plays   a   central   role   in   the   expansion   and maintenance of regulatory T cells, although it inhibits   the development of Th17 polarized cells . Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity.

基本信息：

别名(synonym)：Human IL2; IL-2; IL-2; IL2; interleukin-2

来源(Source)：Human embryonic kidney cell, HEK293-derived human IL2 protein 

蛋白结构（Structure): 该蛋白不含标签

基因 ID：P60568

氨基酸序列：Ala21-Thr153

分子量大小(MW): 15.4 kDa 纯度（Purity）: > 95%，determined by SDS-PAGE

制剂(Formulation)：

Solution protein. Dissolved in sterile PBS buffer to a concentration of 0.2 mg/mL. This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening

产品数据：

1. SDS-PAG

2.活性检测（Biological Activity）:

Recombinant Human IL2 (Catalog # CY181F)

stimulates cell proliferation of the CTLL-2 mouse cytotoxic T cell line.